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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Chondroblastoma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Chondroblastoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = abundant (chondroid) extracellular material, chondroblasts (variable nuclear morphology (ovoid, folded or grooved), moderate-abundant eosinophilic cytoplasm), +/-calcifications surrounding the cell nests ("chickenwire" appearance) - classic feature, +/-[[giant cells]] | |||
| Subtypes = | |||
| LMDDx = [[giant cell tumour of bone]], [[chondroma]], well-differentiated [[chondrosarcoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = growth plate - see ''[[chondro-osseous tumours]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = "young" - growth plates open | |||
| Signs = | |||
| Symptoms = painful | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Chondroblastoma''' is a benign [[chondro-osseous tumour]] that afflicts the young (growth plates open). | |||
==General== | |||
*Growth plate lesion. | |||
*Sclerotic margin. | |||
*"Young" = growth plates open. | |||
*Most common in teens. | |||
*Typically painful.<ref name=Ref_PCPBoD8_625>{{Ref PCPBoD8|625}}</ref> | |||
*Radiographic osteolytic lesion of the epiphysis [http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic] | |||
*Rare, 1 % of all bone tumors | |||
*Benign | |||
*Humerus, tibia, femur | |||
==Gross== | |||
*Well-defined lesion. | |||
===Image=== | |||
*[http://www.flickr.com/photos/35441329@N05/4052875138/in/set-72157622681280610 Chondroblastoma (flickr.com/humpath)]. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref> | |||
*Abundant extracellular material - pink on [[H&E stain]] - looks vaguely like cartilage. | |||
*Sometimes described as 'immature cartilage' (very narrow DDX for this type of cartilage) | |||
*Chondroblasts: | |||
**Nuclear morphology variable: ovoid, folded or grooved. | |||
**Moderate-abundant eosinophilic cytoplasm. | |||
*+/-Calcification surrounds the cell nests ("chickenwire" appearance) - '''classic feature'''. | |||
**Cell nests have a thin pale blue rimming. | |||
*+/-[[Giant cells]]. | |||
**May lead to confusion with ''[[giant cell tumour of bone]]''. | |||
**Not infrequently associated with an aneurysmal bone cyst (33%).<ref>{{Cite journal | last1 = Sepah | first1 = YJ. | last2 = Umer | first2 = M. | last3 = Minhas | first3 = K. | last4 = Hafeez | first4 = K. | title = Chondroblastoma of the cuboid with an associated aneurysmal bone cyst: a case report. | journal = J Med Case Rep | volume = 1 | issue = | pages = 135 | month = | year = 2007 | doi = 10.1186/1752-1947-1-135 | PMID = 17999776 }}</ref> | |||
DDx: | |||
*[[Giant cell tumour of bone]]. | |||
*[[Chondroma]]. | |||
*Well-differentiated [[chondrosarcoma]]. | |||
*Chondromyxoid fibroma - also has 'immature cartilage' | |||
*[[Aneurysmal bone cyst]] - dont forget that these may be secondary to another lesion. | |||
===Images=== | |||
<gallery> | |||
Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC) | |||
Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC) | |||
Image:Bone Chondroblastoma Medium Power.jpg|Chicken wire calcification. (SKB) | |||
Image:Bone Chondroblastoma High Power.jpg|Chicken wire calcification. (SKB) | |||
Image:Bone Chondroblastoma and Aneurysmal Bone Cyst Low Power.jpg|Immature cartilage surrounded by aneurysmal bone cyst with giant cells. (SKB) | |||
Image:Bone Chondroblastoma With Aneurysmal Bone Cyst - Medium Power.jpg|Immature cartilage (left) abutting aneurysmal bone cyst (right) with giant cells. (SKB) | |||
Image:Bone Chondroblastoma - Medium Power.jpg|Immature cartilage. (SKB) | |||
</gallery> | |||
www: | |||
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | |||
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | |||
*[http://path.upmc.edu/cases/case494/images/fig2a.jpg Chondroblastoma (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case494.html http://path.upmc.edu/cases/case494.html]. Accessed on: 24 January 2012.</ref> | |||
*Tumor Library - case with giant cells[http://www.tumorlibrary.com/case/image.jsp?title=Chondroblastoma+-+Distal+femur+-+Photomicrograph&uri=/case/images/3571.jpg] | |||
==IHC== | |||
Features:<ref name=Ref_WMSP_642>{{Ref WMSP|642}}</ref> | |||
*S100 +ve. | |||
*Vimentin +ve.<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | |||
==See also== | |||
*[[Chondro-osseous tumours]]. | |||
*Tumor Library[http://www.tumorlibrary.com/case/list.jsp?order=diagnosis+ASC&diagnosis=Chondroblastoma] | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Chondro-osseous tumours]] |
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