Difference between revisions of "Chondro-osseous tumours"

Jump to navigation Jump to search

Chondro-osseous tumours (view source)

Revision as of 02:36, 26 May 2010

16 bytes added ,  02:36, 26 May 2010
reorder
(format)
(reorder)
Line 40: Line 40:
*Immature hematopoeitic cells adjacent to the bone.
*Immature hematopoeitic cells adjacent to the bone.


==Infectious==
=Infectious=
===Osteomyelitis===
==Osteomyelitis==
General
General
*Hematogenous - often in children.
*Hematogenous - often in children.
*Direct entry (skin defect) - adults with diabetes.
*Direct entry (skin defect) - adults with diabetes.


====Microscopic====
===Microscopic===
*PMNs.
*PMNs.


===Chronic osteomyelitis===
==Chronic osteomyelitis==
*Plasma cells.
*Plasma cells.
**May be sterile, i.e. no organisms.
**May be sterile, i.e. no organisms.


==Bone tumours==
=Bone tumours=
General:
==General==
*Metastasis:primary bone tumours = >20:1.<ref>WMSP P.632.</ref>
*Metastasis:primary bone tumours = >20:1.<ref>WMSP P.632.</ref>
===Common malignant===
*Osteosarcoma.
*Chondrosarcoma.
*Ewing's sarcoma.
*Multiple myeloma.
*Metastases.
**Most common tumours metastatic to bone (mnemonic: ''BLT with Ketchup & Pickles''):
***Breast.
***Liver.
***Thyroid.
***Kidney.
***Prostate.
Epidemiology:<ref>TN05 OR42.</ref>
*Osteosarcoma -> 2nd decade.
*Ewing's ->5-20 yrs.
*Chondrosarcoma -> from enchondroma or osteochrondroma -- patients over 40 yrs.
*Multiple myeloma -> most common primary bone tumour in adults.
===Malignant bone tumours by age===
Most common by age:<ref>TN05 OR42.</ref>
*<1 year old - neuroblastoma.
*1-10 years old - Ewing's of tubular bones.
*10-30 years old - osteosarcoma, Ewing's of flat bones.
*30-40 years old - reticulum cell sarcoma, fibrosarcoma, parosteal osteosarcoma, malignant giant cell tumour, lymphoma.
*>40 years old - mets, multiple myeloma, chondrosarcoma.
===Benign aggressive bone tumours===
*Giant cell tumours.
*Osteoblastoma.
**Thought to be related to osteoid osteoma.
**If in long bones often diaphyseal.
Ref.:<ref>TN05 OR41.</ref><ref>URL: [http://www.emedicine.com/RADIO/topic494.htm http://www.emedicine.com/RADIO/topic494.htm].</ref>


==Giant cell tumour==
==Giant cell tumour==
Line 132: Line 166:
**Neuroblastoma (possibly).
**Neuroblastoma (possibly).
*Several other translocations exist.
*Several other translocations exist.
==Pigmented villonodular synovitis==
*Commonly abbreviated: ''PVNS''.
*Course: benign.
===Microscopy===
Features:<ref>[http://www.wheelessonline.com/ortho/pigmented_villonodular_synovitis http://www.wheelessonline.com/ortho/pigmented_villonodular_synovitis]</ref>
*Subsynovial nodules composed of cells with:
**Abundant cytoplasm.
**Pale nuclei.
*Multinucleated giant cells.
*Hemosiderin-laden macrophages.
*Foam cells.


==Osteosarcoma==
==Osteosarcoma==
Line 159: Line 180:
**Tumours typically very cellular - when compared to normal bone.
**Tumours typically very cellular - when compared to normal bone.
*Large (multinucleated) osteoclast-like giant cells may be seen.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref>
*Large (multinucleated) osteoclast-like giant cells may be seen.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref>
=Other=
==Pigmented villonodular synovitis==
*Commonly abbreviated: ''PVNS''.
*Course: benign.
===Microscopy===
Features:<ref>[http://www.wheelessonline.com/ortho/pigmented_villonodular_synovitis http://www.wheelessonline.com/ortho/pigmented_villonodular_synovitis]</ref>
*Subsynovial nodules composed of cells with:
**Abundant cytoplasm.
**Pale nuclei.
*Multinucleated giant cells.
*Hemosiderin-laden macrophages.
*Foam cells.


==Adamantinoma==
==Adamantinoma==
Line 175: Line 210:
Features:
Features:
*Fibrous tumour.
*Fibrous tumour.
==Common malignant==
*Osteosarcoma.
*Chondrosarcoma.
*Ewing's sarcoma.
*Multiple myeloma.
*Metastases.
**Most common tumours metastatic to bone (mnemonic: ''BLT with Ketchup & Pickles''):
***Breast.
***Liver.
***Thyroid.
***Kidney.
***Prostate.
Epi.<ref>TN05 OR42.</ref>
*Osteosarcoma -> 2nd decade.
*Ewing's ->5-20 yrs.
*Chondrosarcoma -> from enchondroma or osteochrondroma -- patients over 40 yrs.
*Multiple myeloma -> most common primary bone tumour in adults.
==Malignant bone tumours by age==
Most common by age:<ref>TN05 OR42.</ref>
*<1 year old - neuroblastoma.
*1-10 years old - Ewing's of tubular bones.
*10-30 years old - osteosarcoma, Ewing's of flat bones.
*30-40 years old - reticulum cell sarcoma, fibrosarcoma, parosteal osteosarcoma, malignant giant cell tumour, lymphoma.
*>40 years old - mets, multiple myeloma, chondrosarcoma.
==Benign aggressive bone tumours==
*Giant cell tumours.
*Osteoblastoma.
**Thought to be related to osteoid osteoma.
**If in long bones often diaphyseal.
Ref.:<ref>TN05 OR41.</ref><ref>URL: [http://www.emedicine.com/RADIO/topic494.htm http://www.emedicine.com/RADIO/topic494.htm].</ref>


==Brown cell tumour==
==Brown cell tumour==
Michael
48,466

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/437"

Navigation menu