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Difference between revisions of "Chondro-osseous tumours"
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→Chondrosarcoma: expand
(→Ewing sarcoma: clarify) |
(→Chondrosarcoma: expand) |
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==Chondrosarcoma== | ==Chondrosarcoma== | ||
===General=== | ===General=== | ||
*Usually a good prognosis. | |||
Clinical/epidemiologic features:<ref name=pmid17976362>{{cite journal |author=Skubitz KM, D'Adamo DR |title=Sarcoma |journal=Mayo Clin. Proc. |volume=82 |issue=11 |pages=1409–32 |year=2007 |month=November |pmid=17976362 |doi= |url=http://www.mayoclinicproceedings.com/content/82/11/1409.long}}</ref> | Clinical/epidemiologic features:<ref name=pmid17976362>{{cite journal |author=Skubitz KM, D'Adamo DR |title=Sarcoma |journal=Mayo Clin. Proc. |volume=82 |issue=11 |pages=1409–32 |year=2007 |month=November |pmid=17976362 |doi= |url=http://www.mayoclinicproceedings.com/content/82/11/1409.long}}</ref> | ||
*Usually arise in a (benign) abnormality of cartilage (e.g. osteochondroma, enchondroma). | *Usually arise in a (benign) abnormality of cartilage (e.g. osteochondroma, enchondroma). | ||
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref>IAV. 26 February 2009.</ref> | Features:<ref>IAV. 26 February 2009.</ref><ref name=Ref_Klatt417>{{Ref Klatt|417}}</ref> | ||
*"Abnormal cartilage": | *"Abnormal cartilage" (esp. low power): | ||
**Nuclear atypia. | **Nuclear atypia. | ||
***Nuclear clearing. | ***Nuclear clearing. | ||
***Nucleoli. | ***Nucleoli. | ||
Notes: | |||
*More cellular than cartilage... but relatively paucicellular compared to other sarcomas. | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Chondrosarcoma_(2).jpg Chondrosarcoma (WC)]. | *[http://commons.wikimedia.org/wiki/File:Chondrosarcoma_(1).jpg Chondrosarcoma - low mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Chondrosarcoma_(2).jpg Chondrosarcoma - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Chondrosarcoma_(3).jpg Chondrosarcoma - high mag. (WC)]. | |||
DDx: | |||
*[[Chordoma]]. | |||
====Mesenchymal chondrosarcoma==== | ====Variants==== | ||
=====Mesenchymal chondrosarcoma===== | |||
*Arise in soft tissue; this is where the name comes from.<ref name=pmid14161087>{{cite journal |author=Dowling EA |title=Mesenchymal chondrosarcoma |journal=J Bone Joint Surg Am |volume=46 |issue= |pages=747–54 |year=1964 |month=June |pmid=14161087 |doi= |url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref> | *Arise in soft tissue; this is where the name comes from.<ref name=pmid14161087>{{cite journal |author=Dowling EA |title=Mesenchymal chondrosarcoma |journal=J Bone Joint Surg Am |volume=46 |issue= |pages=747–54 |year=1964 |month=June |pmid=14161087 |doi= |url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref> | ||
*Rare variant of chondrosarcoma. | *Rare variant of chondrosarcoma. | ||
Microscopic: | |||
Features: | |||
*"White clouds in a blue sky". | |||
Image: | |||
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)]. | |||
====Grading==== | |||
Features:<ref name=Ref_WMSP643>{{Ref WMSP|643}}</ref> | |||
*Grade I: moderate cellularity +/- binucleated cells. | |||
*Grade III: nuclear pleomorphism, mitoses common. | |||
*Grade II: between Grade I and Grade III. | |||
===IHC=== | |||
*S-100 -ve. (???) | |||
=Bone= | =Bone= | ||