Difference between revisions of "Chondro-osseous tumours"

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Chondro-osseous tumours (view source)

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→‎Giant cell tumour of tendon sheath: split-out
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==Giant cell tumour of tendon sheath==
==Giant cell tumour of tendon sheath==
*Abbreviated ''GCT of tendon sheath''.
*Abbreviated ''GCT of tendon sheath''.
===General===
{{Main|Giant cell tumour of tendon sheath}}
*Can be thought of as the small joint version of [[diffuse tenosynovial giant-cell tumour]] ([[AKA]] ''PVNS'').<ref name=Ref_DCHH341>{{Ref DCHH|341}}</ref>
*Rarely recur.
*Classically afflicts the hand.<ref name=Ref_WMSP612>{{Ref WMSP|612}}</ref>
*Rarely malignant.<ref name=pmid19094761>{{Cite journal  | last1 = Pan | first1 = YW. | last2 = Huang | first2 = XY. | last3 = You | first3 = JF. | last4 = Tian | first4 = GL. | last5 = Li | first5 = C. | title = [Malignant giant cell tumor of the tendon sheaths in the hand]. | journal = Zhonghua Wai Ke Za Zhi | volume = 46 | issue = 21 | pages = 1645-8 | month = Nov | year = 2008 | doi =  | PMID = 19094761 }}</ref><ref name=pmid8230758>{{Cite journal  | last1 = Shinjo | first1 = K. | last2 = Miyake | first2 = N. | last3 = Takahashi | first3 = Y. | title = Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. | journal = Jpn J Clin Oncol | volume = 23 | issue = 5 | pages = 317-24 | month = Oct | year = 1993 | doi =  | PMID = 8230758 }}</ref>
 
===Gross===
Features:<ref name=Ref_WMSP612>{{Ref WMSP|612}}</ref>
*Circumscribed mass - yellow-brown to tan.
 
Note:
*May be associated with bony erosions in larger lesions.<ref name=Ref_WMSP612>{{Ref WMSP|612}}</ref>
 
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122708/figure/Fig2/ GCT of tendon sheath (nih.gov)].<ref name=pmid22282671>{{Cite journal  | last1 = Suresh | first1 = SS. | last2 = Zaki | first2 = H. | title = Giant cell tumor of tendon sheath: case series and review of literature. | journal = J Hand Microsurg | volume = 2 | issue = 2 | pages = 67-71 | month = Dec | year = 2010 | doi = 10.1007/s12593-010-0020-9 | PMID = 22282671 }}</ref>
 
===Microscopic===
Features:<ref name=Ref_DCHH341>{{Ref DCHH|341-2}}</ref>
*Foam cells.
**Cells with moderate to abundant foamy-appearing cytoplasm.
*Multinucleated giant cells - may be scarce.
*+/-Tendon.
**Dense connective tissue.
*+/-Hemosiderin-laden macrophages.
 
Note:
*Features of malignancy: nuclear pleomorphism,<ref name=pmid8230758>{{Cite journal  | last1 = Shinjo | first1 = K. | last2 = Miyake | first2 = N. | last3 = Takahashi | first3 = Y. | title = Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. | journal = Jpn J Clin Oncol | volume = 23 | issue = 5 | pages = 317-24 | month = Oct | year = 1993 | doi =  | PMID = 8230758 }}</ref> abnormal mitoses, >10 mitoses/[[HPF]], tumour necrosis lack of maturation to superficial part (nuclei shrink, cytoplasm lipid-ified).<ref name=Ref_DCHH341>{{Ref DCHH|341-2}}</ref>
 
DDx:
*[[Giant cell lesions]].
 
====Images====
<gallery>
Image:Giant_cell_tumor_of_tendon_sheath_histopathology%281%29.jpg | GCT of tendon sheath. (WC/KGH)
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=1&Case=484 GCT of tendon sheath - very low mag. (webpathology.com)]
*[http://www.webpathology.com/image.asp?case=484&n=5 GCT of tendon sheath - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=4&Case=484 GCT of tendon sheath - high mag. (webpathology.com)].
 
===Sign out===
<pre>
LESION, RIGHT INDEX FINGER, EXCISION:
- GIANT CELL TUMOUR OF THE TENDON SHEATH.
</pre>
 
====Micro====
The sections show histiocytes and rare multinucleated giant cells on a background of dense connective tissue compatible with tendon.  No nuclear atypia is apparent.  Rare mitotic activity is identified.  No atypical mitoses are apparent.
 
=====Alternate=====
The sections show histiocytes and rare multinucleated giant cells on a background of dense
connective tissue compatible with tendon. Hemosiderin-laden macrophages are present. No
nuclear atypia is apparent. No mitotic activity is apparent.


==Adamantinoma==
==Adamantinoma==
Michael
48,453

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