48,436
edits
Difference between revisions of "Cholesteatoma"
Jump to navigation
Jump to search
→Microscopic
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Consistent with cholesteatoma -- low mag.jpg | |||
| Width = | |||
| Caption = Keratinaceous debris consistent with cholesteatoma. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = keratinaceous debris (key feature), +/-squamous epithelium, +/-macrophages and giant cells giant cell, +/-chronic inflammation (lymphocytes) | |||
| Subtypes = | |||
| LMDDx = cholesterol granuloma, [[squamous cell carcinoma]], [[epidermal inclusion cyst]] - history different | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = middle ear - see ''[[head and neck pathology]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-family history, +/-history of trauma | |||
| Signs = whitish mass in the middle ear | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Cholesteatoma''' is a [[head and neck pathology]] [[ditzel]]. | |||
==General== | ==General== | ||
| Line 16: | Line 48: | ||
*Whitish mass in the middle ear.<ref name=pmid23217274>{{Cite journal | last1 = Al Balushi | first1 = T. | last2 = Naik | first2 = JZ. | last3 = Al Khabori | first3 = M. | title = Congenital cholesteatoma in identical twins. | journal = J Laryngol Otol | volume = 127 | issue = 1 | pages = 67-9 | month = Jan | year = 2013 | doi = 10.1017/S0022215112002757 | PMID = 23217274 }}</ref> | *Whitish mass in the middle ear.<ref name=pmid23217274>{{Cite journal | last1 = Al Balushi | first1 = T. | last2 = Naik | first2 = JZ. | last3 = Al Khabori | first3 = M. | title = Congenital cholesteatoma in identical twins. | journal = J Laryngol Otol | volume = 127 | issue = 1 | pages = 67-9 | month = Jan | year = 2013 | doi = 10.1017/S0022215112002757 | PMID = 23217274 }}</ref> | ||
Image | ===Image=== | ||
<gallery> | <gallery> | ||
Image:Cholesteatom_kuppelraum_1a.jpg | Cholesteatoma. (WC) | Image:Cholesteatom_kuppelraum_1a.jpg | Cholesteatoma. (WC) | ||
| Line 31: | Line 63: | ||
*Cholesterol granuloma.<ref>URL: [http://path.upmc.edu/cases/case273/dx.html http://path.upmc.edu/cases/case273/dx.html]. Accessed on: 14 January 2012.</ref> | *Cholesterol granuloma.<ref>URL: [http://path.upmc.edu/cases/case273/dx.html http://path.upmc.edu/cases/case273/dx.html]. Accessed on: 14 January 2012.</ref> | ||
*[[Squamous cell carcinoma]].<ref name=pmid19563937/> | *[[Squamous cell carcinoma]].<ref name=pmid19563937/> | ||
*[[Epidermal inclusion cyst]] - history different.{{ | *[[Epidermal inclusion cyst]] - history different. | ||
**Obscure immunostains different.<ref name=pmid7515549>{{Cite journal | last1 = Dallari | first1 = S. | last2 = Cavani | first2 = A. | last3 = Bergamini | first3 = G. | last4 = Girolomoni | first4 = G. | title = Integrin expression in middle ear cholesteatoma. | journal = Acta Otolaryngol | volume = 114 | issue = 2 | pages = 188-92 | month = Mar | year = 1994 | doi = | PMID = 7515549 }}</ref> | |||
===Images=== | |||
<gallery> | |||
Image: Consistent with cholesteatoma -- very low mag.jpg | Cholesteatoma --very low mag. | |||
Image: Consistent with cholesteatoma -- low mag.jpg | Cholesteatoma -- low mag. | |||
Image: Consistent with cholesteatoma -- intermed mag.jpg | Cholesteatoma -- intermed. mag. | |||
Image: Consistent with cholesteatoma - alt -- intermed mag.jpg | Cholesteatoma -- intermed. mag. | |||
Image: Consistent with cholesteatoma -- high mag.jpg | Cholesteatoma -- high mag. | |||
</gallery> | |||
==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
Submitted as " | Submitted as "Left Mastoid Cholesteatoma", Excision: | ||
- Keratinaceous debris and benign squamous epithelium, consistent with cholesteatoma. | - Keratinaceous debris and benign squamous epithelium, consistent with cholesteatoma. | ||
| Line 42: | Line 84: | ||
<pre> | <pre> | ||
Soft tissue, left ear ("left ear keratosis"), excision: | Soft tissue, left ear ("left ear keratosis"), excision: | ||
- Keratinaceous debris, squamous epithelium and bone (consistent with cholesteatoma). | - Keratinaceous debris, squamous epithelium and bone (consistent with cholesteatoma). | ||
</pre> | </pre> | ||
===Block letters=== | ===Block letters=== | ||
| Line 54: | Line 96: | ||
- KERATINACEOUS DEBRIS AND GIANT CELLS, COMPATIBLE WITH CHOLESTEATOMA. | - KERATINACEOUS DEBRIS AND GIANT CELLS, COMPATIBLE WITH CHOLESTEATOMA. | ||
</pre> | </pre> | ||
===Micro=== | |||
The section shows keratinaceous debris and benign squamous epithelium with a granular layer. There is no significant cellular atypia and giant cells are not present. | |||
==See also== | ==See also== | ||