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Difference between revisions of "Celiac sprue"
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'''Celiac sprue''' is a common pathology that affects the [[duodenum]]. | '''Celiac sprue''', also '''celiac disease''', is a common pathology that affects the [[duodenum]]. | ||
An introduction to gastrointestinal pathology is in the ''[[gastrointestinal pathology]]'' article. It covers basic gastrointestinal histology. | An introduction to gastrointestinal pathology is in the ''[[gastrointestinal pathology]]'' article. It covers basic gastrointestinal histology. | ||
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Most pathologists do not grade celiac sprue. | Most pathologists do not grade celiac sprue. | ||
The most common system is the '' | The most common system is the ''Marsh system'' (abbreviated):<ref>{{cite journal |author=Oberhuber G, Granditsch G, Vogelsang H |title=The histopathology of coeliac disease: time for a standardized report scheme for pathologists |journal=Eur J Gastroenterol Hepatol |volume=11 |issue=10 |pages=1185–94 |year=1999 |month=October |pmid=10524652 |doi= |url=}}</ref><ref name=pmid12145668>{{cite journal |author=Wahab PJ, Meijer JW, Dumitra D, Goerres MS, Mulder CJ |title=Coeliac disease: more than villous atrophy |journal=Rom J Gastroenterol |volume=11 |issue=2 |pages=121–7 |year=2002 |month=June |pmid=12145668 |doi= |url=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
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| Blunted villi | | Blunted villi | ||
| Flattened mucosa | | Flattened mucosa | ||
|} | |||
The ''Marsh system'' (full):<ref>{{cite journal |author=Oberhuber G, Granditsch G, Vogelsang H |title=The histopathology of coeliac disease: time for a standardized report scheme for pathologists |journal=Eur J Gastroenterol Hepatol |volume=11 |issue=10 |pages=1185–94 |year=1999 |month=October |pmid=10524652 |doi= |url=}}</ref> | |||
{| class="wikitable" | |||
| Marsh score | |||
| Descriptors | |||
| Alternate descriptors | |||
| Crypts | |||
| IEL | |||
|- | |||
| Marsh 0 | |||
| Well-formed villi | |||
| Normal villous arch. | |||
| | |||
| | |||
|- | |||
| Marsh 1 | |||
| Well-formed villi | |||
| Normal villous arch. | |||
| | |||
| | |||
|- | |||
| March 2 | |||
| Well-formed villi | |||
| Normal villous arch. | |||
| | |||
| | |||
|- | |||
| Marsh 3A | |||
| Partial villous atrophy | |||
| Blunted villi | |||
| | |||
| | |||
|- | |||
| Marsh 3B | |||
| Partial villous atrophy | |||
| Blunted villi | |||
| | |||
| | |||
|- | |||
| Marsh 3C | |||
| Total villous atrophy | |||
| Flattened mucosa | |||
| | |||
| | |||
|} | |} | ||