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Difference between revisions of "Case 59"
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→Chromosomal translocations: +clonality testing
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(→Chromosomal translocations: +clonality testing) |
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===Provided clinical history=== | ===Provided clinical history=== | ||
73 year old woman, sigmoidectomy for foreign body perforation | |||
===Site=== | ===Site=== | ||
lymph node from sigmoidectomy specimen | |||
===Primary image=== | ===Primary image=== | ||
[[Image: | [[Image: Chronic lymphocytic leukemia - low mag.jpg |500px|link=|center|]] | ||
<center>Low magnification. [[H&E stain]].</center> | <center>Low magnification. [[H&E stain]].</center> | ||
{{hidden|Intermediate magnification|[[Image: | {{hidden|Intermediate magnification|[[Image: Chronic lymphocytic leukemia - intermed mag.jpg |500px|link=|center|]] | ||
<center>Intermediate magnification. [[H&E stain]].</center>}} | <center>Intermediate magnification. [[H&E stain]].</center>}} | ||
{{hidden|High magnification|[[Image: | {{hidden|High magnification|[[Image: Chronic lymphocytic leukemia - high mag.jpg |500px|link=|center|]] | ||
<center>High magnification. [[H&E stain]].</center>}} | <center>High magnification. [[H&E stain]].</center>}} | ||
<!-- | |||
===Differential diagnosis=== | ===Differential diagnosis=== | ||
{{hidden|Differential diagnosis|<center>THE DDx GOES HERE</center>}} | {{hidden|Differential diagnosis|<center>THE DDx GOES HERE</center>}} | ||
--> | |||
===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>Chicken bone lead to sigmoid perforation. Large lymph node found during operation - sent to pathology. Mild leukocytosis.</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center> | {{hidden|Ask a colleague|<center>Could be neoplastic... did you do stains?</center>}} | ||
====Stains==== | ====Stains==== | ||
| Line 82: | Line 82: | ||
| b72_3= | | b72_3= | ||
| bcatenin= | | bcatenin= | ||
| bcl2= | | bcl2= '''POSITIVE''' | ||
| bcl6= | | bcl6= | ||
| bclxl= | | bclxl= | ||
| Line 90: | Line 90: | ||
| calretinin= | | calretinin= | ||
| cam5p2= | | cam5p2= | ||
| cd10= | | cd10= '''NEGATIVE''' | ||
| cd117= | | cd117= | ||
| cd138= | | cd138= | ||
| cd15= | | cd15= | ||
| cd1a= | | cd1a= | ||
| cd20= | | cd20= '''POSITIVE''' | ||
| cd21= | | cd21= | ||
| cd23= | | cd23= '''POSITIVE''' | ||
| cd3= | | cd3= mostly '''NEGATIVE''' | ||
| cd30= | | cd30= | ||
| cd31= | | cd31= | ||
| Line 105: | Line 105: | ||
| cd4= | | cd4= | ||
| cd43= | | cd43= | ||
| cd45= '''POSITIVE''' | |||
| cd45= | | cd45= | ||
| cd5= '''POSITIVE''' | |||
| cd5= | |||
| cd56= | | cd56= | ||
| cd57= | | cd57= | ||
| Line 127: | Line 127: | ||
| cmv= | | cmv= | ||
| cmyc= | | cmyc= | ||
| cyclin_d1= | | cyclin_d1= '''NEGATIVE''' | ||
| d2_40= | | d2_40= | ||
| desmin= | | desmin= | ||
| Line 216: | Line 216: | ||
| wt1= | | wt1= | ||
}} | }} | ||
====Chromosomal translocations==== | |||
====Molecular testing==== | |||
=====Chromosomal translocations===== | |||
{{Case Translocations | {{Case Translocations | ||
| blank=Dr Torres would ask why! | | blank=Dr Torres would ask why! | ||
| Line 239: | Line 241: | ||
| tx_17= | | tx_17= | ||
| tx_18= | | tx_18= | ||
}} | |||
=====Other molecular tests===== | |||
{{Case Molecular | |||
| blank=Dr Torres would ask why! | |||
| alk = | |||
| b_cell_clone = Clonality '''PRESENT''' | |||
| bcl2 = | |||
| braf = | |||
| EBV_pcr = | |||
| egrf = | |||
| h3f3a = | |||
| hhv8_pcr = | |||
| identity_test = | |||
| idh1_2 = | |||
| jak2_v617f = | |||
| kit = | |||
| loh_1p19q = | |||
| t_cell_clone = Clonality '''ABSENT''' | |||
}} | }} | ||
===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center> | {{hidden|Diagnosis|<center>[[Small lymphocytic lymphoma]]</center>}} | ||
<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||
| Line 251: | Line 271: | ||
[[Category:Cases]] | [[Category:Cases]] | ||
[[Category:Cases in hematopathology]] | |||
[[Category:Cases in | [[Category:Cases in hematopathology - junior]] | ||
- | [[Category:Cases in lymph node pathology]] | ||
[[Category:Cases in lymph node pathology - junior]] | |||
[[Category:Cases difficulty | [[Category:Cases difficulty 3]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | ||