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Difference between revisions of "Carcinosarcoma"
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'''Carcinosarcoma''' is a tumour with a malignant epithelial and a malignant mesenchymal component, based on histomorphology. | [[Image:Carcinosarcoma - high mag.jpg|thumb|right|Micrograph showing a carcinosarcoma. [[H&E stain]].]] | ||
'''Carcinosarcoma''' is a tumour with a malignant epithelial component ([[carcinoma]]) and a malignant mesenchymal component ([[sarcoma]]), based on the histomorphology. | |||
They can arise in a number of sites: | They can arise in a number of sites: | ||
| Line 5: | Line 6: | ||
*Ovarian carcinosarcoma. | *Ovarian carcinosarcoma. | ||
*Fallopian tube carcinosarcoma. | *Fallopian tube carcinosarcoma. | ||
==Relation of carcinosarcoma to metaplastic carcinoma and sarcomatoid carcinoma== | |||
''Carcinosarcoma'' implies that the tumour arose from mesenchymal cells and epithelial cells simultaneously. | |||
This is in contradistinction to: | |||
# [[Sarcomatoid carcinoma]] - implies the tumour arose from epithelial cells only and is sarcoma-like (morphologically), and | |||
# [[Metaplastic carcinoma]] - implies the tumour arose from epithelial cells that had undergone a (morphologic) transformation (metaplasia). | |||
Uterine carcinosarcomas are generally considered [[metaplastic carcinoma]]s.<ref name=pmid25805398>{{Cite journal | last1 = Cantrell | first1 = LA. | last2 = Blank | first2 = SV. | last3 = Duska | first3 = LR. | title = Uterine carcinosarcoma: A review of the literature. | journal = Gynecol Oncol | volume = 137 | issue = 3 | pages = 581-588 | month = Jun | year = 2015 | doi = 10.1016/j.ygyno.2015.03.041 | PMID = 25805398 }}</ref><ref name=pmid25468677>{{Cite journal | last1 = Artioli | first1 = G. | last2 = Wabersich | first2 = J. | last3 = Ludwig | first3 = K. | last4 = Gardiman | first4 = MP. | last5 = Borgato | first5 = L. | last6 = Garbin | first6 = F. | title = Rare uterine cancer: carcinosarcomas. Review from histology to treatment. | journal = Crit Rev Oncol Hematol | volume = 94 | issue = 1 | pages = 98-104 | month = Apr | year = 2015 | doi = 10.1016/j.critrevonc.2014.10.013 | PMID = 25468677 }}</ref> They typically metastasize as [[carcinoma]]s,<ref name=pmid21309261>{{Cite journal | last1 = Lopez-Garcia | first1 = MA. | last2 = Palacios | first2 = J. | title = Pathologic and molecular features of uterine carcinosarcomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 274-86 | month = Nov | year = 2010 | doi = | PMID = 21309261 }}</ref> and putatively arise from epithelial cells (only). | |||
The term ''carcinosarcoma'' is from the morphologic era of pathology;{{fact}} it precedes the modern battery of molecular tests and [[immunohistochemistry]]. | |||
==See also== | |||
*[[Adenosarcoma]]. | |||
*[[Sarcomatoid carcinoma]]. | |||
*[[Metaplastic carcinoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
{{disambiguation}} | {{disambiguation}} | ||
[[Category:Gynecologic pathology]] | [[Category:Gynecologic pathology]] | ||