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Difference between revisions of "Carcinoma ex pleomorphic adenoma"
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Carcinoma ex pleomorphic adenoma (view source)
Revision as of 01:42, 26 December 2014
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Carcinoma ex pleomorphic adenoma -- low mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Carcinoma ex pleomorphic adenoma. [[H&E stain]]. | ||
| Micro = epithelial or myoepithelial cells with cytologic features of malignancy, pleomorphic adenoma (required if no | | Micro = epithelial or myoepithelial cells with cytologic features of malignancy, pleomorphic adenoma (required if no history) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]] | | LMDDx = [[salivary duct carcinoma]], [[mucoepidermoid carcinoma]], [[adenoid cystic carcinoma]], [[pleomorphic adenoma]] | ||
| Line 45: | Line 45: | ||
==Gross== | ==Gross== | ||
*Usually mass lesion - typically | *Usually mass lesion - typically parotid gland.<ref name=pmid21744105/> | ||
==Microscopic== | ==Microscopic== | ||
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===Images=== | ===Images=== | ||
<gallery> | |||
Image: Carcinoma ex pleomorphic adenoma -- very low mag.jpg | Ca ex PA - very low mag. | |||
Image: Carcinoma ex pleomorphic adenoma -- low mag.jpg | Ca ex PA - low mag. | |||
Image: Carcinoma ex pleomorphic adenoma - a1 -- low mag.jpg | Ca ex PA - low mag. | |||
Image: Carcinoma ex pleomorphic adenoma - a2 -- low mag.jpg | Ca ex PA - low mag. | |||
Image: Carcinoma ex pleomorphic adenoma -- intermed mag.jpg | Ca ex PA - intermed. mag. | |||
Image: Carcinoma ex pleomorphic adenoma - a1 -- intermed mag.jpg | Ca ex PA - intermed. mag. | |||
Image: Carcinoma ex pleomorphic adenoma -- high mag.jpg | Ca ex PA - high mag. | |||
Image: Carcinoma ex pleomorphic adenoma -- very high mag.jpg | Ca ex PA - very high mag. | |||
</gallery> | |||
www: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig1/ Ca ex PA - showing ca and PA areas (nih.gov)].<ref name=pmid21744105/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig1/ Ca ex PA - showing ca and PA areas (nih.gov)].<ref name=pmid21744105/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig2/ Ca ex PA - showing capsule invasion (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311945/figure/Fig2/ Ca ex PA - showing capsule invasion (nih.gov)]. | ||
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*CK7 +ve. | *CK7 +ve. | ||
*AE1/AE3 +ve. | *AE1/AE3 +ve. | ||
==Sign out== | |||
<pre> | |||
PAROTID GLAND (MASS), LEFT, EXCISION: | |||
- CARCINOMA EX PLEOMORPHIC ADENOMA, LOW-GRADE, INTRACAPSULAR. | |||
-- MARGINS NEGATIVE. | |||
-- SEE TUMOUR SUMMARY AND COMMENTS. | |||
- THREE BENIGN LYMPH NODES. | |||
</pre> | |||
===Micro=== | |||
The sections show a lesion with spindled (myoepithelial) cells and an epithelial component, | |||
on a background of a chondromyxoid stroma. The lesion is encapsulated by a thin layer of | |||
fibrous tissue. | |||
Focally, within the lesion, nuclear atypia and mitotic activity are identified, including an atypical mitotic figure. The atypical region stains with p53. Approximately 45% of the atypical cells stain with Ki-67. There is no appreciable HER2 staining. | |||
Unremarkable parotid gland and lymph nodes are present. | |||
==See also== | ==See also== | ||