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Difference between revisions of "Carbonic anhydrase 9"
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'''Carbonic anhydrase 9''', abbreviated '''CA9''', is a common [[immunostain]] used in [[genitourinary pathology]]. | '''Carbonic anhydrase 9''', abbreviated '''CA9''', is a common [[immunostain]] used in [[genitourinary pathology]]. | ||
==Positive== | ==General== | ||
*Several clones available - ''M75'' most common.<ref name=pmid18300814>{{Cite journal | last1 = Al-Ahmadie | first1 = HA. | last2 = Alden | first2 = D. | last3 = Qin | first3 = LX. | last4 = Olgac | first4 = S. | last5 = Fine | first5 = SW. | last6 = Gopalan | first6 = A. | last7 = Russo | first7 = P. | last8 = Motzer | first8 = RJ. | last9 = Reuter | first9 = VE. | title = Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing 2 antibodies. | journal = Am J Surg Pathol | volume = 32 | issue = 3 | pages = 377-82 | month = Mar | year = 2008 | doi = 10.1097/PAS.0b013e3181570343 | PMID = 18300814 }}</ref> | |||
==Staining== | |||
===Positive=== | |||
*[[Clear cell renal cell carcinoma]].<ref name=pmid21088149>{{Cite journal | last1 = Genega | first1 = EM. | last2 = Ghebremichael | first2 = M. | last3 = Najarian | first3 = R. | last4 = Fu | first4 = Y. | last5 = Wang | first5 = Y. | last6 = Argani | first6 = P. | last7 = Grisanzio | first7 = C. | last8 = Signoretti | first8 = S. | title = Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade. | journal = Am J Clin Pathol | volume = 134 | issue = 6 | pages = 873-9 | month = Dec | year = 2010 | doi = 10.1309/AJCPPPR57HNJMSLZ | PMID = 21088149 }}</ref> | *[[Clear cell renal cell carcinoma]].<ref name=pmid21088149>{{Cite journal | last1 = Genega | first1 = EM. | last2 = Ghebremichael | first2 = M. | last3 = Najarian | first3 = R. | last4 = Fu | first4 = Y. | last5 = Wang | first5 = Y. | last6 = Argani | first6 = P. | last7 = Grisanzio | first7 = C. | last8 = Signoretti | first8 = S. | title = Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade. | journal = Am J Clin Pathol | volume = 134 | issue = 6 | pages = 873-9 | month = Dec | year = 2010 | doi = 10.1309/AJCPPPR57HNJMSLZ | PMID = 21088149 }}</ref> | ||
==Negative== | ===Negative=== | ||
*[[Xp11.2 translocation carcinoma]].<ref name=pmid21088149/> | *[[Xp11.2 translocation carcinoma]].<ref name=pmid21088149/> | ||