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Difference between revisions of "CDX2"
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*Intestinal adenocarcinomas. | *Intestinal adenocarcinomas. | ||
**[[Colorectal adenocarcinoma]] ~ 90% of cases.<ref name=pmid13679455/> | **[[Colorectal adenocarcinoma]] ~ 90% of cases.<ref name=pmid13679455/> | ||
*[[Neuroendocrine tumours]].<ref name=pmid15640551>{{cite journal |authors=Erickson LA, Papouchado B, Dimashkieh H, Zhang S, Nakamura N, Lloyd RV |title=Cdx2 as a marker for neuroendocrine tumors of unknown primary sites |journal=Endocr Pathol |volume=15 |issue=3 |pages=247–52 |date=2004 |pmid=15640551 |doi=10.1385/ep:15:3:247 |url=}}</ref> | |||
====Sometimes positive==== | ====Sometimes positive==== | ||
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===Negative=== | ===Negative=== | ||
*[[Lung adenocarcinoma]] -ve | *[[Lung adenocarcinoma]] -ve. | ||
**<5% +ve in 20 cases.<ref name=pmid17549351>{{Cite journal | last1 = Tanaka | first1 = S. | last2 = Saito | first2 = K. | last3 = Ito | first3 = T. | last4 = Tajima | first4 = K. | last5 = Mogi | first5 = A. | last6 = Shitara | first6 = Y. | last7 = Sano | first7 = T. | last8 = Kuwano | first8 = H. | title = CDX2 as a useful marker of colorectal adenocarcinoma metastases to lung in pre-operative biopsy specimens. | journal = Oncol Rep | volume = 18 | issue = 1 | pages = 87-92 | month = Jul | year = 2007 | doi = | PMID = 17549351 }}</ref> | |||
**~12% of 93 cases +ve, all positive cases TTF-1 +ve and napsin A +ve.<ref name=pmid26469326>{{Cite journal | last1 = Cowan | first1 = ML. | last2 = Li | first2 = QK. | last3 = Illei | first3 = PB. | title = CDX-2 Expression in Primary Lung Adenocarcinoma. | journal = Appl Immunohistochem Mol Morphol | volume = 24 | issue = 1 | pages = 16-9 | month = Jan | year = 2016 | doi = 10.1097/PAI.0000000000000250 | PMID = 26469326 }}</ref> | |||
*[[Choroid plexus papilloma]]s -ve (0 in 65 cases<ref name=pmid19795349>{{Cite journal | last1 = Beschorner | first1 = R. | last2 = Mittelbronn | first2 = M. | last3 = Mugler | first3 = M. | last4 = Meyermann | first4 = R. | last5 = Schittenhelm | first5 = J. | title = Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors. | journal = Histol Histopathol | volume = 24 | issue = 12 | pages = 1507-14 | month = Dec | year = 2009 | doi = | PMID = 19795349 }}</ref>). | *[[Choroid plexus papilloma]]s -ve (0 in 65 cases<ref name=pmid19795349>{{Cite journal | last1 = Beschorner | first1 = R. | last2 = Mittelbronn | first2 = M. | last3 = Mugler | first3 = M. | last4 = Meyermann | first4 = R. | last5 = Schittenhelm | first5 = J. | title = Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors. | journal = Histol Histopathol | volume = 24 | issue = 12 | pages = 1507-14 | month = Dec | year = 2009 | doi = | PMID = 19795349 }}</ref>). | ||
*[[Pituitary adenoma]] & [[Craniopharyngioma]] (0 in 75 and 0 in 23 cases <ref name=pmid20602288> {{Cite journal | last1 = Schittenhelm | first1 = J. | last2 = Psaras | first2 = T. | last3 = Meyermann | first3 = R. | last4 = Honegger | first4 = J. | last5 = Beschorner | first5 = R. | title = Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. | journal = Folia Neuropathol | volume = 48 | issue = 2 | pages = 75-80 | month = | year = 2010 | doi = | PMID = 20602288 }}</ref>). | *[[Pituitary adenoma]] & [[Craniopharyngioma]] (0 in 75 and 0 in 23 cases <ref name=pmid20602288> {{Cite journal | last1 = Schittenhelm | first1 = J. | last2 = Psaras | first2 = T. | last3 = Meyermann | first3 = R. | last4 = Honegger | first4 = J. | last5 = Beschorner | first5 = R. | title = Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. | journal = Folia Neuropathol | volume = 48 | issue = 2 | pages = 75-80 | month = | year = 2010 | doi = | PMID = 20602288 }}</ref>). | ||