Difference between revisions of "CDX2"

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(→‎Negative: DDx metastatic vs epithelial tumours of the CNS)
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===Negative===
===Negative===
*[[Lung adenocarcinoma]] -ve (<5% +ve in 20 cases<ref name=pmid17549351>{{Cite journal  | last1 = Tanaka | first1 = S. | last2 = Saito | first2 = K. | last3 = Ito | first3 = T. | last4 = Tajima | first4 = K. | last5 = Mogi | first5 = A. | last6 = Shitara | first6 = Y. | last7 = Sano | first7 = T. | last8 = Kuwano | first8 = H. | title = CDX2 as a useful marker of colorectal adenocarcinoma metastases to lung in pre-operative biopsy specimens. | journal = Oncol Rep | volume = 18 | issue = 1 | pages = 87-92 | month = Jul | year = 2007 | doi =  | PMID = 17549351 }}</ref>).
*[[Lung adenocarcinoma]] -ve (<5% +ve in 20 cases<ref name=pmid17549351>{{Cite journal  | last1 = Tanaka | first1 = S. | last2 = Saito | first2 = K. | last3 = Ito | first3 = T. | last4 = Tajima | first4 = K. | last5 = Mogi | first5 = A. | last6 = Shitara | first6 = Y. | last7 = Sano | first7 = T. | last8 = Kuwano | first8 = H. | title = CDX2 as a useful marker of colorectal adenocarcinoma metastases to lung in pre-operative biopsy specimens. | journal = Oncol Rep | volume = 18 | issue = 1 | pages = 87-92 | month = Jul | year = 2007 | doi =  | PMID = 17549351 }}</ref>).
*[[Choroid plexus papilloma]]s -ve (0 in 65 cases<ref name=pmid19795349>{{Cite journal  | last1 = Beschorner | first1 = R. | last2 = Mittelbronn | first2 = M. | last3 = Mugler | first3 = M. | last4 = Meyermann | first4 = R. | last5 = Schittenhelm | first5 = J. | title = Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors. | journal = Histol Histopathol | volume = 24 | issue = 12 | pages = 1507-14 | month = Dec | year = 2009 | doi =  | PMID = 19795349 }}</ref>).
*[[Pituitary adenoma]] & [[Craniopharyngioma]] (0 in 75 and 0 in 23 cases <ref name=pmid20602288> {{Cite journal  | last1 = Schittenhelm | first1 = J. | last2 = Psaras | first2 = T. | last3 = Meyermann | first3 = R. | last4 = Honegger | first4 = J. | last5 = Beschorner | first5 = R. | title = Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. | journal = Folia Neuropathol | volume = 48 | issue = 2 | pages = 75-80 | month =  | year = 2010 | doi =  | PMID = 20602288 }}</ref>).


==References==
==References==

Revision as of 09:00, 5 October 2015

CDX2
Immunostain in short

CDX2 immunostaining in the papillary thyroid carcinoma cribriform morular variant.
Abbreviation CDX2
Normal staining pattern nuclear
Positive colorectal adenocarcinoma, small bowel adenocarcinoma, yolk sac tumour, ovarian mucinous adenocarcinoma
Negative lung adenocarcinoma

CDX2 is a commonly used immunostain in pathology. It is a nuclear stain.

Normal

  • Intestinal epithelium.[1]

Pathology

Positive

Negative or positive

Negative

References

  1. 1.0 1.1 Groisman, GM.; Meir, A.; Sabo, E. (Jan 2004). "The value of Cdx2 immunostaining in differentiating primary ovarian carcinomas from colonic carcinomas metastatic to the ovaries.". Int J Gynecol Pathol 23 (1): 52-7. doi:10.1097/01.pgp.0000101141.31270.a0. PMID 14668551.
  2. Bing, Z.; Pasha, T.; Tomaszewski, JE.; Zhang, P. (Oct 2009). "CDX2 expression in yolk sac component of testicular germ cell tumors.". Int J Surg Pathol 17 (5): 373-7. doi:10.1177/1066896909338598. PMID 19578052.
  3. Jun, SY.; Eom, DW.; Park, H.; Bae, YK.; Jang, KT.; Yu, E.; Hong, SM. (Mar 2014). "Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma.". Mod Pathol. doi:10.1038/modpathol.2014.36. PMID 24603585.
  4. Tanaka, S.; Saito, K.; Ito, T.; Tajima, K.; Mogi, A.; Shitara, Y.; Sano, T.; Kuwano, H. (Jul 2007). "CDX2 as a useful marker of colorectal adenocarcinoma metastases to lung in pre-operative biopsy specimens.". Oncol Rep 18 (1): 87-92. PMID 17549351.
  5. Beschorner, R.; Mittelbronn, M.; Mugler, M.; Meyermann, R.; Schittenhelm, J. (Dec 2009). "Immunohistochemical analysis of CDX2 expression in normal choroid plexus epithelium and choroid plexus tumors.". Histol Histopathol 24 (12): 1507-14. PMID 19795349.
  6. Schittenhelm, J.; Psaras, T.; Meyermann, R.; Honegger, J.; Beschorner, R. (2010). "Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms.". Folia Neuropathol 48 (2): 75-80. PMID 20602288.