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Difference between revisions of "Brenner tumour"
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| Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests | | Micro = nests cells that have a "[[coffee bean nucleus]]" (nucleus = elliptical shape, nuclear groove along long axis), distinct nucleoli, moderate-to-abundant gray/pale cytoplasm, dense fibrous stroma around nests | ||
| Subtypes = benign (most common), borderline, malignant | | Subtypes = benign (most common), borderline, malignant | ||
| LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]] | | LMDDx = [[granulosa cell tumour]], [[ovarian fibroma]], [[thecoma]], [[Walthard cell rest]] | ||
| Stains = | | Stains = | ||
| IHC = AR +ve, calretinin -ve | | IHC = AR +ve, calretinin -ve | ||
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**Serous carcinoma. | **Serous carcinoma. | ||
**Metastatic urothelial carcinoma. | **Metastatic urothelial carcinoma. | ||
*[[Walthard cell rest]] - typically one nest of cells, lacks the surrounding fibromatous stroma. | |||
===Images=== | ===Images=== | ||
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==IHC== | ==IHC== | ||
Features:<ref>{{Cite journal | last1 = Kuhn | first1 = E. | last2 = Ayhan | first2 = A. | last3 = Shih | first3 = IeM. | last4 = Seidman | first4 = JD. | last5 = Kurman | first5 = RJ. | title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. | journal = Eur J Cancer | volume = 49 | issue = 18 | pages = 3839-49 | month = Dec | year = 2013 | doi = 10.1016/j.ejca.2013.08.011 | PMID = 24012099 }}</ref> | Features:<ref name=pmid24012099>{{Cite journal | last1 = Kuhn | first1 = E. | last2 = Ayhan | first2 = A. | last3 = Shih | first3 = IeM. | last4 = Seidman | first4 = JD. | last5 = Kurman | first5 = RJ. | title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. | journal = Eur J Cancer | volume = 49 | issue = 18 | pages = 3839-49 | month = Dec | year = 2013 | doi = 10.1016/j.ejca.2013.08.011 | PMID = 24012099 }}</ref> | ||
*AR +ve. | *[[Androgen receptor|AR]] +ve. | ||
*Calretinin -ve. | *Calretinin -ve. | ||
**Surrounding stroma +ve. | **Surrounding stroma +ve. | ||
*Inhibin +ve.<ref name=pmid24012099>{{ | *Inhibin +ve.<ref name=pmid24012099>{{Cite journal | last1 = Kuhn | first1 = E. | last2 = Ayhan | first2 = A. | last3 = Shih | first3 = IeM. | last4 = Seidman | first4 = JD. | last5 = Kurman | first5 = RJ. | title = Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium. | journal = Eur J Cancer | volume = 49 | issue = 18 | pages = 3839-49 | month = Dec | year = 2013 | doi = 10.1016/j.ejca.2013.08.011 | PMID = 24012099 }}</ref> | ||
==See also== | ==See also== | ||