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Difference between revisions of "Brain metastasis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg | |||
| Width = | |||
| Caption = Metastatic adenocarcinoma, compatible with colorectal primary. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = usu. well-demarcated border between brain and lesion, no cytoplasmic processes (seen in glial tumours), usu. have [[nuclear atypia]] of malignancy, +/-glandular architecture, +/-nucleoli seen | |||
| Subtypes = | |||
| LMDDx = primary brain tumour | |||
| Stains = | |||
| IHC = GFAP -ve, dependent on primary - typical +ve for keratins | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[brain]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = intra-axial, typically cerebellum or grey-white junction | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = primary brain tumour, abscess | |||
| Tx = surgery, chemotherapy, radiation therapy | |||
}} | |||
'''Brain metastasis''', also '''metastatic brain tumour''', is a [[brain tumour]] that arose elsewhere and spread to the brain. | '''Brain metastasis''', also '''metastatic brain tumour''', is a [[brain tumour]] that arose elsewhere and spread to the brain. | ||
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*Percentage of previously diagnosed cancers with brain metastases - by primary site: lung cancer 19.9%, melanoma 6.9%, breast cancer 5.1%, renal cancer 6.5%, colorectal cancer 1.8%.<ref name=pmid15254054>{{Cite journal | last1 = Barnholtz-Sloan | first1 = JS. | last2 = Sloan | first2 = AE. | last3 = Davis | first3 = FG. | last4 = Vigneau | first4 = FD. | last5 = Lai | first5 = P. | last6 = Sawaya | first6 = RE. | title = Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. | journal = J Clin Oncol | volume = 22 | issue = 14 | pages = 2865-72 | month = Jul | year = 2004 | doi = 10.1200/JCO.2004.12.149 | PMID = 15254054 }}</ref> | *Percentage of previously diagnosed cancers with brain metastases - by primary site: lung cancer 19.9%, melanoma 6.9%, breast cancer 5.1%, renal cancer 6.5%, colorectal cancer 1.8%.<ref name=pmid15254054>{{Cite journal | last1 = Barnholtz-Sloan | first1 = JS. | last2 = Sloan | first2 = AE. | last3 = Davis | first3 = FG. | last4 = Vigneau | first4 = FD. | last5 = Lai | first5 = P. | last6 = Sawaya | first6 = RE. | title = Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. | journal = J Clin Oncol | volume = 22 | issue = 14 | pages = 2865-72 | month = Jul | year = 2004 | doi = 10.1200/JCO.2004.12.149 | PMID = 15254054 }}</ref> | ||
**''Lung'' followed by ''kidney'' is the order in a smaller series.<ref>{{Cite journal | last1 = Schouten | first1 = LJ. | last2 = Rutten | first2 = J. | last3 = Huveneers | first3 = HA. | last4 = Twijnstra | first4 = A. | title = Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. | journal = Cancer | volume = 94 | issue = 10 | pages = 2698-705 | month = May | year = 2002 | doi = | PMID = 12173339 }}</ref> | **''Lung'' followed by ''kidney'' is the order in a smaller series.<ref>{{Cite journal | last1 = Schouten | first1 = LJ. | last2 = Rutten | first2 = J. | last3 = Huveneers | first3 = HA. | last4 = Twijnstra | first4 = A. | title = Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. | journal = Cancer | volume = 94 | issue = 10 | pages = 2698-705 | month = May | year = 2002 | doi = | PMID = 12173339 }}</ref> | ||
==Gross/Radiology== | |||
*Intra-axial location. | |||
**Typically at the grey-white junction.<ref name=pmid19727563>{{Cite journal | last1 = Della Puppa | first1 = A. | last2 = Dal Pos | first2 = S. | last3 = Zovato | first3 = S. | last4 = Orvieto | first4 = E. | last5 = Ciccarino | first5 = P. | last6 = Manara | first6 = R. | last7 = Zustovich | first7 = F. | last8 = Berti | first8 = F. | last9 = Gardiman | first9 = MP. | title = Solitary intra-ventricular brain metastasis from a breast carcinoma. | journal = J Neurooncol | volume = 97 | issue = 1 | pages = 123-6 | month = Mar | year = 2010 | doi = 10.1007/s11060-009-9988-z | PMID = 19727563 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||