Bizarre parosteal osteochondromatous proliferation

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Bizarre parosteal osteochondromatous proliferation
Diagnosis in short

Synonyms Nora lesion
Site Hands, feet


General

A distinctive osteochondromatous proliferation of hands and feet.

Population

  • Young adults
  • 20s-30s

Location

Hands and feet

Radiology

Marginated wide based bony growth projecting into the soft tissues[1]

Gross

  • Nodule covered with glistening cartilage

Microscopic

Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.

Images

DDX

  • Periosteal chondrosarcoma
  • Periosteal chondroma
  • Low grade parosteal osteosarcoma
  • Osteochondroma

Diangostic categories

  • Cartilaginous neoplasms
  • Osteocartilaginous neoplasms

Molecular

t(1:17)(q32;q21)[2]

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  • BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
  • APPROPRIATE MARGIN STATEMENT.

Prognosis

  • Benign
  • Locally aggressive

See also

  • Pathology Outlines[5]

References

  1. http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation
  2. Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.