Bile duct adenoma

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Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.

It is also known as a benign bile duct proliferation.[1]

General

  • Benign.
  • Important as it can be misdiagnosed as cancer.

Microscopic

Features:

  • Disordered bile ducts within in a fibrotic stroma.
    • No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
    • +/-Lymphocytic cuff.

Negatives:

  • No mitotic activity.
  • No necrosis.

DDx:

Images

IHC

  • CK7 +ve.
  • HepPar-1 -ve.
  • Ki-67 low.

Others:[2]

  • p53 -ve.
  • mCEA -ve.

See also

References

  1. Johannesen, EJ.; Wu, Z.; Holly, JS. (2014). "Bile duct adenoma with oncocytic features.". Case Rep Pathol 2014: 282010. doi:10.1155/2014/282010. PMID 24592348.
  2. 2.0 2.1 Hornick, JL.; Lauwers, GY.; Odze, RD. (Mar 2005). "Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver.". Am J Surg Pathol 29 (3): 381-9. PMID 15725808.