Bile duct adenoma

Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.

It is also known as a benign bile duct proliferation.

General

• Benign.
• Important as it can be misdiagnosed as cancer.

Microscopic

Features:

• Disordered bile ducts within in a fibrotic stroma.
  • No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
  • +/-Lymphocytic cuff.

Negatives:

• No mitotic activity.
• No necrosis.

DDx:

• Cholangiocarcinoma.
• Metastatic adenocarcinoma.
• Bile duct hamartoma (von Meyenburg complex).

Images

• Bile duct adenoma (ganfyd.org).

IHC

• CK7 +ve.
• HepPar-1 -ve.
• HMGA1 -ve/+ve.
• HMGA2 -ve/+ve.

Note:

• HMGA1 & HMGA2 together may be useful for differentiating from adenocarcioma.

See also

• Liver neoplasms.