Difference between revisions of "Bile duct adenoma"
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===Images=== | ===Images=== | ||
*[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)]. | *[http://www.ganfyd.org/index.php?title=Image:Bile_duct_adenoma_low_power.jpg Bile duct adenoma (ganfyd.org)]. | ||
==IHC== | |||
*CK7 +ve. | |||
*HepPar-1 -ve. | |||
*HMGA1 -ve/+ve. | |||
*HMGA2 -ve/+ve. | |||
Note: | |||
*HMGA1 & HMGA2 together may be useful for differentiating from adenocarcioma.<ref name=pmid23530587>{{Cite journal | last1 = Zakharov | first1 = V. | last2 = Ren | first2 = B. | last3 = Ryan | first3 = C. | last4 = Cao | first4 = W. | title = Diagnostic value of HMGAs, p53 and β-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. | journal = Histopathology | volume = 62 | issue = 5 | pages = 778-87 | month = Apr | year = 2013 | doi = 10.1111/his.12084 | PMID = 23530587 }} | |||
</ref> | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Liver neoplasms]] | [[Category:Liver neoplasms]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 01:20, 7 March 2014
Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.
It is also known as a benign bile duct proliferation.[1]
General
- Benign.
- Important as it can be misdiagnosed as cancer.
Microscopic
Features:
- Disordered bile ducts within in a fibrotic stroma.
- No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
- +/-Lymphocytic cuff.
Negatives:
- No mitotic activity.
- No necrosis.
DDx:
- Cholangiocarcinoma.
- Metastatic adenocarcinoma.
- Bile duct hamartoma (von Meyenburg complex).
Images
IHC
- CK7 +ve.
- HepPar-1 -ve.
- HMGA1 -ve/+ve.
- HMGA2 -ve/+ve.
Note:
- HMGA1 & HMGA2 together may be useful for differentiating from adenocarcioma.[2]
See also
References
- ↑ Johannesen, EJ.; Wu, Z.; Holly, JS. (2014). "Bile duct adenoma with oncocytic features.". Case Rep Pathol 2014: 282010. doi:10.1155/2014/282010. PMID 24592348.
- ↑ Zakharov, V.; Ren, B.; Ryan, C.; Cao, W. (Apr 2013). "Diagnostic value of HMGAs, p53 and β-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies.". Histopathology 62 (5): 778-87. doi:10.1111/his.12084. PMID 23530587.