Difference between revisions of "Basics"

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Basics (view source)

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*''Argyrophilic'' means has an affinity for silver<ref>URL: [http://www.merriam-webster.com/medical/argyrophilic http://www.merriam-webster.com/medical/argyrophilic]. Accessed on: 29 August 2011.</ref><ref>URL: [http://en.wiktionary.org/wiki/argyrophilic http://en.wiktionary.org/wiki/argyrophilic]. Accessed on: 29 August 2011.</ref>/loves silver/stains with silver.
*''Argyrophilic'' means has an affinity for silver<ref>URL: [http://www.merriam-webster.com/medical/argyrophilic http://www.merriam-webster.com/medical/argyrophilic]. Accessed on: 29 August 2011.</ref><ref>URL: [http://en.wiktionary.org/wiki/argyrophilic http://en.wiktionary.org/wiki/argyrophilic]. Accessed on: 29 August 2011.</ref>/loves silver/stains with silver.
===Morphologic patterns===
===Morphologic patterns===
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
{{Main|Morphologic patterns}}
! Name of pattern
This covers things like ''cribriform'', ''hobnail'', ''herring bone'' and many others.
! Meaning
! DDx (incomplete/abbrev. list)
! Image
|-
| Hobnail
| basement membrane area < area exposed to luminal surface
| [[angiosarcoma]], clear cell carcinoma
| [[Image:Epithelioid_angiosarcoma_-_very_high_mag.jpg |thumb|center|150px| [[Angiosarcoma]] - very high mag. (WC/Nephron)]]
|-
| Storiform
| spiral appearance ''or'' cartwhell pattern<ref>Storiform. dictionary.com. URL: [http://dictionary.reference.com/browse/storiform http://dictionary.reference.com/browse/storiform]. Accessed on: April 24, 2009.</ref>
| [[solitary fibrous tumour]], [[DFSP]], [[dermatofibroma]], [[UPS]]
| [[Image:Storiform_pattern_-_very_high_mag.jpg | thumb| center|150px| [[DFSP]] - very high mag. (WC/Nephron)]]
|-
| Fascicular
| the long axis of the (spindle) cells are perpendicular to one another in adjacent bundles of cells
| [[leiomyoma]], [[leiomyosarcoma]]
| [[Image:Cutaneous_leiomyosarcoma_-_very_high_mag.jpg| thumb | center | 150px | [[Leiomyosarcoma]] - very high mag. (WC/Nephron)]]
|-
| Plexiform
| web-like formation<ref>URL: [http://www.mondofacto.com/facts/dictionary?plexiform http://www.mondofacto.com/facts/dictionary?plexiform]. Accessed on: March 9, 2010.</ref>
| [[plexiform neurofibroma]], [[MPNST]], plexiform lesion of [[pulmonary hypertension]]
| [http://www.flickr.com/photos/bc_the_path/1715728630/ plexiform lesion of Pulm. HTn (flickr.com)]
|-
| Cribriform
| pierced with small holes<ref>URL: [http://dictionary.reference.com/browse/cribriform http://dictionary.reference.com/browse/cribriform]. Accessed on: 8 August 2011.</ref>
| cribriform [[DCIS]], cribriform [[HGPIN]], cribriforming in a [[tubular adenoma of the gastrointestinal tract|tubular adenoma]] with high-grade dysplasia, endometrioid endometrial carcinoma
| [[Image:Atypical_ductal_hyperplasia_-_very_high_mag.jpg|thumb|center|150px|Cribriform architecure ([[ADH]]) - very high mag. (WC/Nephron)]]
|-
| Solid ''or'' Sheeting
| no architecture - back-to-back cells with no pattern apparent / no spaces between cells
| solid DCIS, poorly-differentiated malignancy (carcinoma, sarcoma, lymphoma)
| [[Image:Merkel_cell_carcinoma_-_high_mag.jpg|thumb|center|150px|Sheeting in a [[Merkel cell carcinoma]] - high mag. (WC/Nephron)]]
|-
| Micropapillary
| nipple like projections without a fibrovascular core (papillary = nipple-like<ref>URL: [http://dictionary.reference.com/browse/papillary http://dictionary.reference.com/browse/papillary]. Accessed on: 8 August 2011.</ref>)
| micropapillary [[DCIS]], micropapillary [[HGPIN]]
| [[File:Invasive_micropapillary_carcinoma_of_the_breast.jpg|thumb|center|150px|Micropapillary carcinoma. (WC)]]
|-
| Papillary
| nipple-like projection with a fibrovascular core
| [[papillary thyroid carcinoma]]
| [[Image:Papillary_renal_cell_carcinoma_high_mag.jpg| thumb|center|150px|[[Papillary RCC]] - high mag. (WC/Nephron)]]
|-
| Flat
| board-like, does not have a projection above the surface
| flat DCIS
| [http://www.breastpathology.info/Sloane/Images/dcis/flat1-400.jpg flat DCIS 1 (breastpathology.info)],<ref name=sloane/> [http://www.breastpathology.info/Sloane/Images/dcis/flat2-400.jpg flat DCIS 2 (breastpathology.info)]<ref name=sloane>URL: [http://www.breastpathology.info/Sloane/dcis.html http://www.breastpathology.info/Sloane/dcis.html]. Accessed on: 8 August 2011.</ref>
|-
| Herring bone
| like herring bone (technique) for climbing a hill in cross country skiing; books on a shelf, where they have partially fallen over -- on the one shelf to the left and the one below to the right
| [[fibrosarcoma]], [[synovial sarcoma]], [[MPNST]]
| [[Image:Malignant_peripheral_nerve_sheath_tumour_-_high_mag.jpg|thumb|center|150px| [[MPNST]] - high mag.(WC/Nephron)]]
|-
| [[Trabecular]] ''or'' cords
| trabecula = ''little beam''<ref>URL: [http://dictionary.reference.com/browse/trabecula http://dictionary.reference.com/browse/trabecula]. Accessed on: 26 December 2010.</ref>; quasi-linear arrangement of cells
| normal liver lobule, [[Sertoli cell tumour]]
| [[Image:Papillary thyroid carcinoma tall cell var high mag.jpg|thumb|center|150px|[[PTC]] tall cell variant - high mag. (WC/Nephron)]]
|-
| Nested (nesting)
| islands of cells with a circular outline
| neuroendocrine tumours
| [[Image:Small_intestine_neuroendocrine_tumour_high_mag_cropped.jpg |thumb|center|150px|[[Neuroendocrine tumour]] - low mag. (WC/Nephron)]]
|-
| Biphasic / multiple patterns
| multiple patterns or cell types; e.g. spindle cells and epithelioid cells
| [[synovial sarcoma]], [[malignant melanoma]], [[pleomorphic adenoma]], [[angiomyolipoma]], [[chondroid syringoma]]
| [[Image:Desmoplastic_small_round_cell_tumour_-_high_mag.jpg |thumb|center|150px| [[DSRCT]] - high mag. (WC/Nephron)]]
|}


===Nuclear destruction words===
===Nuclear destruction words===
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*A collection of PMNs... think about ''necrosis'' and ''abscess''.
*A collection of PMNs... think about ''necrosis'' and ''abscess''.


===Lymph node metstatsis===
===Lymph node metastasis===
{{Main|Lymph node metastasis}}
{{Main|Lymph node metastasis}}
*Take a good to look at the tumour first.
*Take a good to look at the tumour first.
*Tumour in a node is often better differentiated than the most poorly differentiated part in the primary site.
*Tumour in a node is often better differentiated than the most poorly differentiated part in the primary site.
*Subcapsular space - the first place to look for mets.
*Subcapsular space - the first place to look for mets.
*Lymph node metstasis are usually obvious.
*Lymph node metastasis are usually obvious.
**There are of course exceptions, e.g. [[small cell carcinoma]], [[invasive lobular carcinoma]].
**There are of course exceptions, e.g. [[small cell carcinoma]], [[invasive lobular carcinoma]].
*Histiocytes may be difficult to separate from tumour - especially for the novice.
*Histiocytes may be difficult to separate from tumour - especially for the novice.
Michael
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