48,466
edits
Difference between revisions of "Basal crypt dysplasia"
Jump to navigation
Jump to search
→Sign out
| (4 intermediate revisions by the same user not shown) | |||
| Line 3: | Line 3: | ||
It may be referred to as '''crypt dysplasia-like atypia'''<ref name=pmid16625087>{{Cite journal | last1 = Lomo | first1 = LC. | last2 = Blount | first2 = PL. | last3 = Sanchez | first3 = CA. | last4 = Li | first4 = X. | last5 = Galipeau | first5 = PC. | last6 = Cowan | first6 = DS. | last7 = Ayub | first7 = K. | last8 = Rabinovitch | first8 = PS. | last9 = Reid | first9 = BJ. | title = Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort. | journal = Am J Surg Pathol | volume = 30 | issue = 4 | pages = 423-35 | month = Apr | year = 2006 | doi = | PMID = 16625087 }}</ref> and '''crypt dysplasia''' (abbreviated '''CD'''). | It may be referred to as '''crypt dysplasia-like atypia'''<ref name=pmid16625087>{{Cite journal | last1 = Lomo | first1 = LC. | last2 = Blount | first2 = PL. | last3 = Sanchez | first3 = CA. | last4 = Li | first4 = X. | last5 = Galipeau | first5 = PC. | last6 = Cowan | first6 = DS. | last7 = Ayub | first7 = K. | last8 = Rabinovitch | first8 = PS. | last9 = Reid | first9 = BJ. | title = Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort. | journal = Am J Surg Pathol | volume = 30 | issue = 4 | pages = 423-35 | month = Apr | year = 2006 | doi = | PMID = 16625087 }}</ref> and '''crypt dysplasia''' (abbreviated '''CD'''). | ||
The conventional thinking has been that dysplasia ''always'' involve the surface epithelium; BCD violates the saying ''normal is '''d'''ark '''d'''eep and '''l'''ight '''l'''uminal.'' This entity is consider to be an emerging concept;<ref name=pmid21970480>{{Cite journal | last1 = Voltaggio | first1 = L. | last2 = Montgomery | first2 = EA. | last3 = Lam-Himlin | first3 = D. | title = A clinical and histopathologic focus on Barrett esophagus and Barrett-related dysplasia. | journal = Arch Pathol Lab Med | volume = 135 | issue = 10 | pages = 1249-60 | month = Oct | year = 2011 | doi = 10.5858/arpa.2011-0019-RA | PMID = 21970480 }}</ref> it is not completely without controversy. | |||
BCD violates the saying ''normal is '''d'''ark '''d'''eep and '''l'''ight '''l'''uminal.'' | |||
==General== | ==General== | ||
*Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/> | *Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/> | ||
*Strong association with conventional dysplasia/adenocarcinoma. | *Strong association with conventional dysplasia/adenocarcinoma. | ||
**In one series, 87% of individual with BCD had dysplasia ''or'' adenocarcinoma in other tissue samples.<ref name=pmid16625087/> | **In one series, 87% of individual with BCD had [[columnar dysplasia of the esophagus|columnar dysplasia]] ''or'' [[esophageal adenocarcinoma|adenocarcinoma]] in other tissue samples.<ref name=pmid16625087/> | ||
*Reproducibility among pathologists is worse than [[columnar dysplasia of the esophagus|high-grade dysplasia]] but better than low-grade dysplasia.<ref name=pmid21970480/> | |||
==Microscopic== | ==Microscopic== | ||
| Line 19: | Line 18: | ||
**Nuclear crowding (pseudostratification). | **Nuclear crowding (pseudostratification). | ||
*Non-dysplastic (normal) surface epithelium.<ref name=pmid23695891/> | *Non-dysplastic (normal) surface epithelium.<ref name=pmid23695891/> | ||
DDx: | |||
*Indefinite for [[columnar dysplasia of the esophagus]]. | |||
*[[Columnar dysplasia of the esophagus]]. | |||
==Sign out== | |||
*Cut levels to look for a definite lesion. | |||
*Probably best to avoid; call it "indefinite for dysplasia". | |||
Note: | |||
*Voltaggio ''et al.'' advocate it should be treated like low-grade dysplasia (requires a follow-up biopsy).<ref name=pmid21970480/> | |||
==See also== | ==See also== | ||