Difference between revisions of "Basal crypt dysplasia"

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It may be referred to as '''crypt dysplasia-like atypia'''<ref name=pmid16625087>{{Cite journal  | last1 = Lomo | first1 = LC. | last2 = Blount | first2 = PL. | last3 = Sanchez | first3 = CA. | last4 = Li | first4 = X. | last5 = Galipeau | first5 = PC. | last6 = Cowan | first6 = DS. | last7 = Ayub | first7 = K. | last8 = Rabinovitch | first8 = PS. | last9 = Reid | first9 = BJ. | title = Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort. | journal = Am J Surg Pathol | volume = 30 | issue = 4 | pages = 423-35 | month = Apr | year = 2006 | doi =  | PMID = 16625087 }}</ref> and '''crypt dysplasia''' (abbreviated '''CD''').
It may be referred to as '''crypt dysplasia-like atypia'''<ref name=pmid16625087>{{Cite journal  | last1 = Lomo | first1 = LC. | last2 = Blount | first2 = PL. | last3 = Sanchez | first3 = CA. | last4 = Li | first4 = X. | last5 = Galipeau | first5 = PC. | last6 = Cowan | first6 = DS. | last7 = Ayub | first7 = K. | last8 = Rabinovitch | first8 = PS. | last9 = Reid | first9 = BJ. | title = Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort. | journal = Am J Surg Pathol | volume = 30 | issue = 4 | pages = 423-35 | month = Apr | year = 2006 | doi =  | PMID = 16625087 }}</ref> and '''crypt dysplasia''' (abbreviated '''CD''').


Conventional dysplasia is said to ''always'' involve the surface epithelium.
The conventional thinking has been that dysplasia ''always'' involve the surface epithelium; BCD violates the saying ''normal is '''d'''ark '''d'''eep and '''l'''ight '''l'''uminal.'' This entity is consider to be an emerging concept;<ref name=pmid21970480>{{Cite journal  | last1 = Voltaggio | first1 = L. | last2 = Montgomery | first2 = EA. | last3 = Lam-Himlin | first3 = D. | title = A clinical and histopathologic focus on Barrett esophagus and Barrett-related dysplasia. | journal = Arch Pathol Lab Med | volume = 135 | issue = 10 | pages = 1249-60 | month = Oct | year = 2011 | doi = 10.5858/arpa.2011-0019-RA | PMID = 21970480 }}</ref> it is not completely without controversy.
 
BCD violates the saying ''normal is '''d'''ark '''d'''eep and '''l'''ight '''l'''uminal.''


==General==
==General==
*Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/>
*Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/>
*Strong association with conventional dysplasia/adenocarcinoma.
*Strong association with conventional dysplasia/adenocarcinoma.
**In one series, 87% of individual with BCD had dysplasia ''or'' adenocarcinoma in other tissue samples.<ref name=pmid16625087/>
**In one series, 87% of individual with BCD had [[columnar dysplasia of the esophagus|columnar dysplasia]] ''or'' [[esophageal adenocarcinoma|adenocarcinoma]] in other tissue samples.<ref name=pmid16625087/>
*Reproducibility among pathologists is worse than [[columnar dysplasia of the esophagus|high-grade dysplasia]] but better than low-grade dysplasia.<ref name=pmid21970480/>


==Microscopic==
==Microscopic==
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**Nuclear crowding (pseudostratification).
**Nuclear crowding (pseudostratification).
*Non-dysplastic (normal) surface epithelium.<ref name=pmid23695891/>
*Non-dysplastic (normal) surface epithelium.<ref name=pmid23695891/>
DDx:
*Indefinite for [[columnar dysplasia of the esophagus]].
*[[Columnar dysplasia of the esophagus]].
==Sign out==
*Cut levels to look for a definite lesion.
*Probably best to avoid; call it "indefinite for dysplasia".
Note:
*Voltaggio ''et al.'' advocate it should be treated like low-grade dysplasia (requires a follow-up biopsy).<ref name=pmid21970480/>


==See also==
==See also==

Latest revision as of 15:33, 10 July 2016

Basal crypt dysplasia, abbreviated BCD, is a dysplastic change reported in the esophagus that involves the crypt bases but not the surface.[1]

It may be referred to as crypt dysplasia-like atypia[2] and crypt dysplasia (abbreviated CD).

The conventional thinking has been that dysplasia always involve the surface epithelium; BCD violates the saying normal is dark deep and light luminal. This entity is consider to be an emerging concept;[3] it is not completely without controversy.

General

  • Molecular changes in the crypt base can be identified in the surface cells.[1]
  • Strong association with conventional dysplasia/adenocarcinoma.
  • Reproducibility among pathologists is worse than high-grade dysplasia but better than low-grade dysplasia.[3]

Microscopic

Features:

  • Definite "dysplastic changes" in the crypt base:
    • Hyperchromasia - important.
    • Nuclear enlargement.
    • Nuclear crowding (pseudostratification).
  • Non-dysplastic (normal) surface epithelium.[1]

DDx:

Sign out

  • Cut levels to look for a definite lesion.
  • Probably best to avoid; call it "indefinite for dysplasia".

Note:

  • Voltaggio et al. advocate it should be treated like low-grade dysplasia (requires a follow-up biopsy).[3]

See also

References

  1. 1.0 1.1 1.2 Khan, S.; McDonald, SA.; Wright, NA.; Graham, TA.; Odze, RD.; Rodriguez-Justo, M.; Zeki, S. (Sep 2013). "Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells.". J Pathol 231 (1): 98-104. doi:10.1002/path.4211. PMID 23695891.
  2. 2.0 2.1 Lomo, LC.; Blount, PL.; Sanchez, CA.; Li, X.; Galipeau, PC.; Cowan, DS.; Ayub, K.; Rabinovitch, PS. et al. (Apr 2006). "Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort.". Am J Surg Pathol 30 (4): 423-35. PMID 16625087.
  3. 3.0 3.1 3.2 Voltaggio, L.; Montgomery, EA.; Lam-Himlin, D. (Oct 2011). "A clinical and histopathologic focus on Barrett esophagus and Barrett-related dysplasia.". Arch Pathol Lab Med 135 (10): 1249-60. doi:10.5858/arpa.2011-0019-RA. PMID 21970480.