Difference between revisions of "Basal crypt dysplasia"
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==General== | ==General== | ||
*Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/> | *Molecular changes in the crypt base can be identified in the surface cells.<ref name=pmid23695891/> | ||
*Strong association with conventional dysplasia/adenocarcinoma. | |||
**In one series, 87% of individual with BCD had dysplasia ''or'' adenocarcinoma in other tissue samples.<ref name=pmid16625087/> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 15:05, 1 April 2014
Basal crypt dysplasia, abbreviated BCD or CD, is a dysplastic change that involves the crypt bases but not the surface.[1]
It may be referred to as crypt dysplasia-like atypia[2] and crypt dysplasia.
General
- Molecular changes in the crypt base can be identified in the surface cells.[1]
- Strong association with conventional dysplasia/adenocarcinoma.
- In one series, 87% of individual with BCD had dysplasia or adenocarcinoma in other tissue samples.[2]
Microscopic
Features:
- Definite "dysplastic changes" in the crypt base:
- Hyperchromasia - important.
- Nuclear enlargement.
- Nuclear crowding (pseudostratification).
- Non-dysplastic (normal) surface epithelium.[1]
See also
References
- ↑ 1.0 1.1 1.2 Khan, S.; McDonald, SA.; Wright, NA.; Graham, TA.; Odze, RD.; Rodriguez-Justo, M.; Zeki, S. (Sep 2013). "Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells.". J Pathol 231 (1): 98-104. doi:10.1002/path.4211. PMID 23695891.
- ↑ 2.0 2.1 Lomo, LC.; Blount, PL.; Sanchez, CA.; Li, X.; Galipeau, PC.; Cowan, DS.; Ayub, K.; Rabinovitch, PS. et al. (Apr 2006). "Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort.". Am J Surg Pathol 30 (4): 423-35. PMID 16625087.