Difference between revisions of "Basal cell carcinoma"

← Older edit

Basal cell carcinoma (view source)

Revision as of 18:45, 15 January 2022

3,274 bytes added , 18:45, 15 January 2022

→‎Images

Marcia

3

edits

@@ Line 1: / Line 1: @@
 {{ Infobox diagnosis
 | Name       = {{PAGENAME}}
 | Image      = Basal_cell_carcinoma_-_high_mag.jpg
 | Width      =
 | Caption    = Basal cell carcinoma. [[H&E stain]].
@@ Line 82: / Line 82: @@
 *Reticulated [[seborrheic keratosis]] - for BCC, fibroepitheliomatous pattern.
 *[[Basaloid squamous cell carcinoma]] - [[AKA]] squamous cell carcinoma, basaloid variant.
-*[[Basosquamous carcinoma]] - squamous cell carcinoma with basal cell carcinoma (a collision tumour).
+*[[Basosquamous carcinoma]] - squamous cell carcinoma with basal cell carcinoma (a [[collision tumour]]).
 *[[Solar elastosis]] with ectatic [[blood vessel]]s.
 *[[Microcystic adnexal carcinoma]] - for sclerosing basal cell carcinoma.
@@ Line 93: / Line 93: @@
 Image:Basal_cell_carcinoma_fibroepitheliomatous_pattern_-_very_low_mag.jpg | Fibroepithelioma of Pinkus. (WC/Nephron)
 Image:SkinTumors-P6040209.JPG | Fibroepithelioma of Pinkus. (WC)
+Fiboepithelioma of Pinkus 10x 4.tif | Fiboepithelioma of Pinkus 10x 4.tif (MLA)
+Fiboepithelioma of Pinkus 10x 3.tif | Fiboepithelioma of Pinkus 10x 3.tif (MLA)
+Fiboepithelioma of Pinkus 10x 2.tif | Fiboepithelioma of Pinkus 10x 2.tif (MLA)
+Fiboepithelioma of Pinkus 10x.tif | Fiboepithelioma of Pinkus 10x.tif (MLA)
+Fibro of pinkus.tif | Fiboepithelioma of Pinkus 4x.tif (MLA)
 </gallery>
+[[File: 5 41110532329262 sl 1.png|Basal cell carcinoma with mucin production]]
+[[File: 5 41110532329262 sl 2.png|Basal cell carcinoma with mucin production]]
+[[File: 5 41110532329262 sl 3.png|Basal cell carcinoma with mucin production]]
+Basal cell carcinoma with mucin production in the left nasal bridge of a 59 year old man, presenting as a presumptive lacrimal cyst. Because of the location, immunohistochemical stains were needed to exclude eccrine tumors and salivary gland type tumors. A. A spheroidal, well circumscribed mass shows intertwining nests (green arrow), isles with cribriforming (yellow arrows), and large acini (cyan arrows), with good circumscription. B. Round to ovoid nuclei show > 4:1 nuclear size variation in some adjacent pairs (black arrows) and occasional pyknotic nuclei (green arrows). Lumens show mucinous material with vacuoles (yellow arrows); the color argues against adenoid cystic carcinoma, but certainty in that respect could not be maintained without immunostains. Note lining up of nuclei suggestive of palisades (blue arrows). C. Nuclei are P63 positive, not shown are the negative stains for SOX10, CK7, and CD117.
 www:
 *[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/basal_cell_carcinoma_high_power.jpg BCC (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/basal_cell_carcinoma.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/basal_cell_carcinoma.html]. Accessed on: 4 September 2011.</ref>
@@ Line 99: / Line 113: @@
 *[http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=930934558 BCC with fibroepitheliomatous pattern (dermatlas.med.jhmi.edu)].
 *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157603/figure/Fig2/ BCC in vitiligo (nih.gov)].<ref name=pmid20623309>{{Cite journal  | last1 = Rustemeyer | first1 = J. | last2 = Günther | first2 = L. | last3 = Deichert | first3 = L. | title = A rare association: basal cell carcinoma in a vitiliginous macula. | journal = Oral Maxillofac Surg | volume = 15 | issue = 3 | pages = 175-7 | month = Sep | year = 2011 | doi = 10.1007/s10006-010-0240-y | PMID = 20623309 }}</ref>
+*[https://dermpath.wordpress.com/category/malignant-cutaneous-neoplasms/basal-cell-carcinoma/ Clear cell BCC (dermpath.wordpress.com)].
 ===Basal cell carcinoma subtypes/unique features===
@@ Line 151: / Line 166: @@
 |-
 | Adenoidal pattern
-| cribriform / pseudoglandular arch.
+| [[cribriform]] / pseudoglandular arch.
 | myxoid stroma, peripheral palisading
 | DDx: [[adenoid cystic carcinoma]]
@@ Line 187: / Line 202: @@
 ==IHC==
-*Ber-EP4 +ve.
+*[[Ber-EP4]] +ve -- typically weak and focal staining.
 **[[Microcystic adnexal carcinoma]] negative.<ref name=pmid23398472 >{{Cite journal  | last1 = Sellheyer | first1 = K. | last2 = Nelson | first2 = P. | last3 = Kutzner | first3 = H. | last4 = Patel | first4 = RM. | title = The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. | journal = J Cutan Pathol | volume = 40 | issue = 4 | pages = 363-70 | month = Apr | year = 2013 | doi = 10.1111/cup.12085 | PMID = 23398472 }}</ref>
-*CK5/6 +ve.
+*CK5/6 +ve (52 of 52<ref name=pmid18496426/>).
 **Useful to assess [[margins]]... if very close.
+*CK7 +ve (30 +ve of 52 cases<ref name=pmid18496426>{{cite journal |authors=Alessi E, Venegoni L, Fanoni D, Berti E |title=Cytokeratin profile in basal cell carcinoma |journal=Am J Dermatopathol |volume=30 |issue=3 |pages=249–55 |date=June 2008 |pmid=18496426 |doi=10.1097/DAD.0b013e31816c828a |url=}}</ref>).
+*CK19 -ve/+ve (14 +ve 52<ref name=pmid18496426/>).
 *CD10 +ve.
 *Actin +ve.
@@ Line 201: / Line 218: @@
 *SMA +ve.<ref>URL: [http://www.ihcworld.com/_newsletter/2004/2004-12_basal_cell_vs_squamous_v1.pdf http://www.ihcworld.com/_newsletter/2004/2004-12_basal_cell_vs_squamous_v1.pdf]. Accessed on: 19 December 2012.</ref>
 **SCC usually negative.
+Other:
+*p63 +ve.<ref name=pmid16630179>{{Cite journal  | last1 = Bircan | first1 = S. | last2 = Candir | first2 = O. | last3 = Kapucoglu | first3 = N. | last4 = Baspinar | first4 = S. | title = The expression of p63 in basal cell carcinomas and association with histological differentiation. | journal = J Cutan Pathol | volume = 33 | issue = 4 | pages = 293-8 | month = Apr | year = 2006 | doi = 10.1111/j.0303-6987.2006.00436.x | PMID = 16630179 }}</ref>
 ==Sign-out==
-<pre>
-SKIN LESION, SHAVE BIOPSY WITH ELECTRODESICCATION AND CURETTAGE (EDC):
-- BASAL CELL CARCINOMA, MARGIN STATUS ASSESSED CLINICALLY DURING EDC.
-- EXTENSIVE SOLAR ELASTOSIS.
-</pre>
 <pre>
 SKIN LESION, RIGHT EAR, EXCISION:
@@ Line 221: / Line 235: @@
 - DERMAL SCAR.
 - EXTENSIVE SOLAR ELASTOSIS.
+</pre>
+===Electrodesiccation and curettage===
+<pre>
+Skin, Left Brow, Biopsy with Electrodesiccation and Curettage (EDC):
+	- BASAL CELL CARCINOMA, margin status assessed clinically during EDC.
+</pre>
+====Block letters====
+<pre>
+SKIN LESION, LEFT FOREARM, SHAVE BIOPSY WITH ELECTRODESICCATION AND CURETTAGE (EDC):
+- BASAL CELL CARCINOMA, MARGIN STATUS ASSESSED CLINICALLY DURING EDC.
+- EXTENSIVE SOLAR ELASTOSIS.
+</pre>
+<pre>
+SKIN LESION, RIGHT UPPER BACK, SHAVE BIOPSY WITH ELECTRODESICCATION AND CURETTAGE (EDC):
+- BASAL CELL CARCINOMA, MARGIN STATUS ASSESSED CLINICALLY DURING EDC.
+- SOLAR ELASTOSIS.
+COMMENT:
+The tumour is clear of the edges of the tissue in the planes of section.
 </pre>
@@ Line 237: / Line 273: @@
 The lateral margins elsewhere are 2-3 millimetres.
 The deep margin is approximately 3 millimetres.
+</pre>
+===Positive lateral margin===
+<pre>
+SKIN LESION, LOWER MID BACK, EXCISION:
+- BASAL CELL CARCINOMA, NODULAR, LATERAL MARGIN POSITIVE.
+-- DEEP MARGIN NEGATIVE.
+- SOLAR ELASTOSIS.
 </pre>

Difference between revisions of "Basal cell carcinoma"

Basal cell carcinoma (view source)

Revision as of 18:45, 15 January 2022

Navigation menu

Search