Difference between revisions of "Atypical polypoid adenomyoma of the uterus"

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#redirect [[Uterine_tumours#Atypical_polypoid_adenomyoma_of_the_uterus]]
'''Atypical polypoid adenomyoma of the uterus''' is a rare benign lesion of the [[uterus]].


It is usually referred to simply as '''atypical polypoid adenomyoma''' (abbreviated '''APA''').
==General==
*Very rare.<ref name=pmid21684185>{{Cite journal  | last1 = Terada | first1 = T. | title = Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 338-41 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.008 | PMID = 21684185 }}</ref>
*Benign.<ref name=pmid17050990/>
*Reproductive age women.
==Gross==
*Lower uterine segment.
==Microscopic==
Features:<ref name=pmid17050990>{{Cite journal  | last1 = Jakus | first1 = S. | last2 = Edmonds | first2 = P. | last3 = Dunton | first3 = C. | last4 = Holland | first4 = G. | title = Atypical polypoid adenomyoma mimicking cervical adenocarcinoma. | journal = J Low Genit Tract Dis | volume = 6 | issue = 1 | pages = 33-8 | month = Jan | year = 2002 | doi =  | PMID = 17050990 }}</ref>
*Glands with irregular (non-ovoid) shapes.
*Benign smooth muscle around the glands - '''key feature'''.
*Morular squamous metaplasia - balls of squamous cells - very common.
*Nuclear atypia (mild).
DDx:
*[[Endometrioid endometrial carcinoma]].
*[[Endometrium with squamous morules]] - more common.
*Endocervical adenocarcinoma.
===Images===
<gallery>
Image:Atypical_polypoid_adenomyoma_-_intermed_mag.jpg | APA - intermed. mag. (WC)
Image:Atypical_polypoid_adenomyoma_-_high_mag.jpg | APA - high mag. (WC)
Image:Atypical_polypoid_adenomyoma_-_very_high_mag.jpg | APA - very high mag. (WC)
</gallery>
www:
*[http://www.pathologypics.com/PictView.aspx?ID=1220 APA (pathologypics.com)].
==IHC==
Features (glandular component):<ref name=pmid21684185/>
*AE1/AE3 +ve.
*CK7 +ve.
*ER +ve.
*PR +ve.
Significant negative (glandular component):<ref name=pmid21684185/>
*[[CK20]] -ve.
*CEA -ve.
==Sign out==
<pre>
ENDOMETRIUM, CURETTAGE:
- ATYPICAL POLYPOID ADENOMYOMA.
COMMENT:
Atypical polypoid adenomyomas are considered to be benign lesions; however,
they may persist or recur in up to half of patients.
</pre>
==See also==
*[[Uterine tumours]].
==References==
{{Reflist|2}}
[[Category:Uterine tumours]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 02:07, 20 March 2014

Atypical polypoid adenomyoma of the uterus is a rare benign lesion of the uterus.

It is usually referred to simply as atypical polypoid adenomyoma (abbreviated APA).

General

  • Very rare.[1]
  • Benign.[2]
  • Reproductive age women.

Gross

  • Lower uterine segment.

Microscopic

Features:[2]

  • Glands with irregular (non-ovoid) shapes.
  • Benign smooth muscle around the glands - key feature.
  • Morular squamous metaplasia - balls of squamous cells - very common.
  • Nuclear atypia (mild).

DDx:

Images

  • APA - intermed. mag. (WC)

  • APA - high mag. (WC)

  • APA - very high mag. (WC)

www:

IHC

Features (glandular component):[1]

  • AE1/AE3 +ve.
  • CK7 +ve.
  • ER +ve.
  • PR +ve.

Significant negative (glandular component):[1]

Sign out

ENDOMETRIUM, CURETTAGE:
- ATYPICAL POLYPOID ADENOMYOMA.

COMMENT:
Atypical polypoid adenomyomas are considered to be benign lesions; however, 
they may persist or recur in up to half of patients.


See also

References

  1. ↑ 1.0 1.1 1.2 Terada, T. (Oct 2011). "Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases.". Ann Diagn Pathol 15 (5): 338-41. doi:10.1016/j.anndiagpath.2011.03.008. PMID 21684185.
  2. ↑ 2.0 2.1 Jakus, S.; Edmonds, P.; Dunton, C.; Holland, G. (Jan 2002). "Atypical polypoid adenomyoma mimicking cervical adenocarcinoma.". J Low Genit Tract Dis 6 (1): 33-8. PMID 17050990.
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