Difference between revisions of "Atypical polypoid adenomyoma of the uterus"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Atypical_polypoid_adenomyoma_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Atypical polypoid adenomyoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = endometrial glands with irregular (non-ovoid) shapes, benign smooth muscle around the glands, morular squamous metaplasia | |||
| Subtypes = | |||
| LMDDx = [[endometrioid endometrial carcinoma]], [[endometrium with squamous morules]], [[endocervical adenocarcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = lower uterine segment lesion | |||
| Grossing = | |||
| Site = [[uterus]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = reproductive age women | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Atypical polypoid adenomyoma of the uterus''' is a rare benign lesion of the [[uterus]]. | |||
It is usually referred to simply as '''''atypical polypoid adenomyoma''''' (abbreviated '''APA'''). | |||
==General== | |||
*Very rare.<ref name=pmid21684185>{{Cite journal | last1 = Terada | first1 = T. | title = Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 338-41 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.008 | PMID = 21684185 }}</ref> | |||
*Benign.<ref name=pmid17050990/> | |||
*Reproductive age women. | |||
==Gross== | |||
*Lower uterine segment. | |||
==Microscopic== | |||
Features:<ref name=pmid17050990>{{Cite journal | last1 = Jakus | first1 = S. | last2 = Edmonds | first2 = P. | last3 = Dunton | first3 = C. | last4 = Holland | first4 = G. | title = Atypical polypoid adenomyoma mimicking cervical adenocarcinoma. | journal = J Low Genit Tract Dis | volume = 6 | issue = 1 | pages = 33-8 | month = Jan | year = 2002 | doi = | PMID = 17050990 }}</ref> | |||
*Glands with irregular (non-ovoid) shapes. | |||
*Benign smooth muscle around the glands - '''key feature'''. | |||
*Morular squamous metaplasia - balls of squamous cells - very common. | |||
*Nuclear atypia (mild). | |||
DDx: | |||
*[[Endometrioid endometrial carcinoma]]. | |||
*[[Endometrium with squamous morules]] - more common. | |||
*[[Endocervical adenocarcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Atypical_polypoid_adenomyoma_-_intermed_mag.jpg | APA - intermed. mag. (WC) | |||
Image:Atypical_polypoid_adenomyoma_-_high_mag.jpg | APA - high mag. (WC) | |||
Image:Atypical_polypoid_adenomyoma_-_very_high_mag.jpg | APA - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.pathologypics.com/PictView.aspx?ID=1220 APA (pathologypics.com)]. | |||
==IHC== | |||
Features (glandular component):<ref name=pmid21684185/> | |||
*AE1/AE3 +ve. | |||
*CK7 +ve. | |||
*ER +ve. | |||
*PR +ve. | |||
Significant negative (glandular component):<ref name=pmid21684185/> | |||
*[[CK20]] -ve. | |||
*CEA -ve. | |||
==Sign out== | |||
<pre> | |||
ENDOMETRIUM, CURETTAGE: | |||
- ATYPICAL POLYPOID ADENOMYOMA. | |||
COMMENT: | |||
Atypical polypoid adenomyomas are considered to be benign lesions; however, | |||
they may persist or recur in up to half of patients. | |||
</pre> | |||
==See also== | |||
*[[Uterine tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Gynecologic pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] |
Latest revision as of 02:13, 20 March 2014
Atypical polypoid adenomyoma of the uterus | |
---|---|
Diagnosis in short | |
Atypical polypoid adenomyoma. H&E stain. | |
| |
LM | endometrial glands with irregular (non-ovoid) shapes, benign smooth muscle around the glands, morular squamous metaplasia |
LM DDx | endometrioid endometrial carcinoma, endometrium with squamous morules, endocervical adenocarcinoma |
Gross | lower uterine segment lesion |
Site | uterus |
| |
Clinical history | reproductive age women |
Prevalence | rare |
Prognosis | benign |
Atypical polypoid adenomyoma of the uterus is a rare benign lesion of the uterus.
It is usually referred to simply as atypical polypoid adenomyoma (abbreviated APA).
General
Gross
- Lower uterine segment.
Microscopic
Features:[2]
- Glands with irregular (non-ovoid) shapes.
- Benign smooth muscle around the glands - key feature.
- Morular squamous metaplasia - balls of squamous cells - very common.
- Nuclear atypia (mild).
DDx:
- Endometrioid endometrial carcinoma.
- Endometrium with squamous morules - more common.
- Endocervical adenocarcinoma.
Images
www:
IHC
Features (glandular component):[1]
- AE1/AE3 +ve.
- CK7 +ve.
- ER +ve.
- PR +ve.
Significant negative (glandular component):[1]
- CK20 -ve.
- CEA -ve.
Sign out
ENDOMETRIUM, CURETTAGE: - ATYPICAL POLYPOID ADENOMYOMA. COMMENT: Atypical polypoid adenomyomas are considered to be benign lesions; however, they may persist or recur in up to half of patients.
See also
References
- ↑ 1.0 1.1 1.2 Terada, T. (Oct 2011). "Atypical polypoid adenomyoma of the uterus: an immunohistochemical study on 5 cases.". Ann Diagn Pathol 15 (5): 338-41. doi:10.1016/j.anndiagpath.2011.03.008. PMID 21684185.
- ↑ 2.0 2.1 Jakus, S.; Edmonds, P.; Dunton, C.; Holland, G. (Jan 2002). "Atypical polypoid adenomyoma mimicking cervical adenocarcinoma.". J Low Genit Tract Dis 6 (1): 33-8. PMID 17050990.