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Difference between revisions of "Atypical lung carcinoid tumour"
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Atypical lung carcinoid tumour (view source)
Revision as of 05:45, 20 April 2016
, 05:45, 20 April 2016tweak
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Atypical lung carcinoid -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Atypical lung carcinoid tumour. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = atypical carcinoid, atypical lung carcinoid, atypical pulmonary carcinoid | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[small cell carcinoma of the lung]], [[carcinoid lung tumour]], [[pulmonary carcinoid tumourlet]], [[lung adenocarcinoma]], metastatic [[small cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = Ki-67 ~17% (range 10-26%) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 26: | Line 26: | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = moderate; poor vis-à-vis typical carcinoid | ||
| Other = | | Other = | ||
| ClinDDx = other [[lung tumours]] | | ClinDDx = other [[lung tumours]] | ||
| Tx = | | Tx = surgical resection +/-chemotherapy | ||
}} | }} | ||
'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours|lung tumour]] with a poor outcome. | '''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours|lung tumour]] with a poor outcome. | ||
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==General== | ==General== | ||
*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref> | *Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref> | ||
Prognosis: | |||
*Significantly worse than for typical carcinoids; in one series,<ref name=pmid26195112>{{Cite journal | last1 = Ayadi-Kaddour | first1 = A. | last2 = Marghli | first2 = A. | last3 = Zairi | first3 = S. | last4 = Zribi | first4 = H. | last5 = Ismail | first5 = O. | last6 = Braham | first6 = E. | last7 = Hantous-Zannad | first7 = S. | last8 = Kilani | first8 = T. | last9 = El Mezni | first9 = F. | title = [Bronchopulmonary carcinoid tumors: Tunisian experience with 115 surgically treated cases]. | journal = Rev Pneumol Clin | volume = 71 | issue = 6 | pages = 319-26 | month = Dec | year = 2015 | doi = 10.1016/j.pneumo.2015.04.003 | PMID = 26195112 }}</ref> the five year survival was 95% and 45% for typical carcinoid and atypical carcinoid respectively. | |||
Treatment: | |||
*Surgery for diagnosis and treatment. | |||
*Chemotherapy for advanced/metastatic disease.<ref name=pmid25218177>{{Cite journal | last1 = Chong | first1 = CR. | last2 = Wirth | first2 = LJ. | last3 = Nishino | first3 = M. | last4 = Chen | first4 = AB. | last5 = Sholl | first5 = LM. | last6 = Kulke | first6 = MH. | last7 = McNamee | first7 = CJ. | last8 = Jänne | first8 = PA. | last9 = Johnson | first9 = BE. | title = Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors. | journal = Lung Cancer | volume = 86 | issue = 2 | pages = 241-6 | month = Nov | year = 2014 | doi = 10.1016/j.lungcan.2014.08.012 | PMID = 25218177 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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*[[Typical carcinoid lung tumour]]. | *[[Typical carcinoid lung tumour]]. | ||
*[[Small cell carcinoma of the lung]]. | *[[Small cell carcinoma of the lung]]. | ||
*Metastatic [[small cell carcinoma]]. | |||
*[[Lung adenocarcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image: Atypical lung carcinoid -- low mag.jpg | ALC - low mag. | |||
Image: Atypical lung carcinoid -- intermed mag.jpg | ALC - intermed. mag. | |||
Image: Atypical lung carcinoid -- high mag.jpg | ALC - high mag. | |||
Image: Atypical lung carcinoid -- very high mag.jpg | ALC - very high mag. | |||
Image: Atypical lung carcinoid - alt -- high mag.jpg | ALC - high mag. | |||
Image: Atypical lung carcinoid - alt -- very high mag.jpg | ALC - very high mag. | |||
Image: Atypical lung carcinoid - alt -- extremely high mag.jpg | ALC - extremely high mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||