Difference between revisions of "Atypical lobular hyperplasia"

From Libre Pathology
Jump to navigation Jump to search
Line 1: Line 1:
'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized cellular proliferation and cellular dyscohesion.
'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized by cellular proliferation and cellular dyscohesion.


It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]].
It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]].

Revision as of 22:03, 28 November 2016

Atypical lobular hyperplasia, abbreviated ALH, a pre-malignant change in the breast characterized by cellular proliferation and cellular dyscohesion.

It can be seen as the precursor to lobular carcinoma in situ, the precursor of lobular carcinoma.

General

  • May occur with ductal involvement by cells of atypical lobular hyperplasia (abbreviated DIALH).[1]
    • ALH with DIALH has a risk of developing breast cancer that is similar to LCIS.

Microscopic

Features:

DDx:

IHC

  • E-cadherin -ve or incomplete membrane staining.

See also

References

  1. Page, DL.; Dupont, WD.; Rogers, LW. (Feb 1988). "Ductal involvement by cells of atypical lobular hyperplasia in the breast: a long-term follow-up study of cancer risk.". Hum Pathol 19 (2): 201-7. PMID 3343034.