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Difference between revisions of "Atypical ductal hyperplasia"
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Atypical ductal hyperplasia (view source)
Revision as of 20:11, 30 April 2016
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'''Atypical ductal hyperplasia''', abbreviated '''ADH''', a benign breast lesion associated with an increased risk of [[malignancy]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Atypical_ductal_hyperplasia_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Atypical ductal hyperplasia. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = | |||
| Micro = cytologic and architectural features of low-grade DCIS (equal cell spacing, lumina round, variable architecture (classically [[cribriform]] or solid - may be micropapillary or papillary), small nuclei, small indistinct nucleoli); limited extent - either (1) two or less complete ducts, (2) <2 mm in size | |||
| Subtypes = | |||
| LMDDx = [[ductal carcinoma in situ]], [[invasive ductal carcinoma of the breast]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[breast]] - see ''[[non-invasive breast carcinoma]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = none | |||
| Prevalence = relatively common | |||
| Bloodwork = | |||
| Rads = suspicious calcifications | |||
| Endoscopy = | |||
| Prognosis = benign, increased risk of malignancy | |||
| Other = | |||
| ClinDDx = | |||
| Tx = lumpectomy when found on biopsy, follow-up if on excisional specimen | |||
}} | |||
'''Atypical ductal hyperplasia''', abbreviated '''ADH''', is a benign [[breast pathology|breast lesion]] associated with an increased risk of [[malignancy]]. | |||
==General== | ==General== | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Cytologic and architectural | *Cytologic and architectural features of low-grade DCIS. | ||
**Cell spacing ~ equal. | **Cell spacing ~ equal. | ||
**Lumina round. | **Lumina round. | ||
| Line 22: | Line 54: | ||
DDx: | DDx: | ||
*Low-grade [[ | *Low-grade [[ductal carcinoma in situ]] (DCIS). | ||
*[[Florid epithelial hyperplasia of the usual type]] (FEHUT). | *[[Florid epithelial hyperplasia of the usual type]] (FEHUT). | ||
| Line 32: | Line 64: | ||
<gallery> | <gallery> | ||
Image:Atypical_ductal_hyperplasia_-_very_low_mag.jpg|ADH. Very low mag. (WC/Nephron) | Image:Atypical_ductal_hyperplasia_-_very_low_mag.jpg|ADH. Very low mag. (WC/Nephron) | ||
Image:Atypical_ductal_hyperplasia_-_low_mag.jpg|ADH - low mag. (WC/Nephron) | |||
Image:Atypical_ductal_hyperplasia_-_intermed_mag.jpg|ADH - intermed. mag. (WC/Nephron) | |||
Image:Atypical_ductal_hyperplasia_-_high_mag.jpg|ADH - high mag. (WC/Nephron) | Image:Atypical_ductal_hyperplasia_-_high_mag.jpg|ADH - high mag. (WC/Nephron) | ||
Image:Atypical_ductal_hyperplasia_-_very_high_mag.jpg|ADH - very high mag. (WC/Nephron) | |||
</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
*CK5 <20% +ve. | *CK5 <20% +ve. | ||
| Line 41: | Line 77: | ||
==See also== | ==See also== | ||
*[[Non-invasive breast carcinoma]]. | *[[Non-invasive breast carcinoma]]. | ||
*[[Ductal carcinoma in situ]]. | |||
*[[Atypical lobular hyperplasia]]. | |||
==References== | ==References== | ||