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Difference between revisions of "Atypical adenomatous hyperplasia of the lung"
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Atypical adenomatous hyperplasia of the lung (view source)
Revision as of 05:14, 24 May 2020
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Atypical_adenomatous_hyperplasia_--_high_mag.jpg | |||
| Width = | |||
| Caption = [[Micrograph]] showing atypical adenomatous hyperplasia. [[H&E stain]]. | |||
| Synonyms = atypical alveolar hyperplasia | |||
| Micro = enlarged alveolar lining cells with [[hobnail morphology]], round or oval hyperchromatic nuclei; spaces are typically seen between the alveolar lining cells '''important'''; limited extent (must be <5 mm); +/-nuclear enlargement (mild-to-moderate), +/-multinucleation | |||
| Subtypes = | |||
| LMDDx = [[adenocarcinoma in situ]] of lung, [[lung adenocarcinoma]], [[multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[lung]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = relatively common | |||
| Bloodwork = | |||
| Rads = ground glass opacity (persistent) | |||
| Endoscopy = | |||
| Prognosis = benign, need to exclude [[lung adenocarcinoma]] | |||
| Other = | |||
| ClinDDx = [[pneumonia]] (chronic), [[lung tumours]] | |||
| Tx = surgical excision | |||
}} | |||
'''Atypical alveolar hyperplasia of the lung''', also '''atypical adenomatous hyperplasia''' (abbreviated '''AAH''') and '''atypical alveolar hyperplasia''', is considered the precursor of [[lung adenocarcinoma]]. It is typically found beside lung adenocarcinoma in resection specimens.<ref name=pmid21252716>{{Cite journal | last1 = Travis | first1 = WD. | last2 = Brambilla | first2 = E. | last3 = Noguchi | first3 = M. | last4 = Nicholson | first4 = AG. | last5 = Geisinger | first5 = KR. | last6 = Yatabe | first6 = Y. | last7 = Beer | first7 = DG. | last8 = Powell | first8 = CA. | last9 = Riely | first9 = GJ. | title = International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. | journal = J Thorac Oncol | volume = 6 | issue = 2 | pages = 244-85 | month = Feb | year = 2011 | doi = 10.1097/JTO.0b013e318206a221 | PMID = 21252716 }}</ref> | '''Atypical alveolar hyperplasia of the lung''', also '''atypical adenomatous hyperplasia''' (abbreviated '''AAH''') and '''atypical alveolar hyperplasia''', is considered the precursor of [[lung adenocarcinoma]]. It is typically found beside lung adenocarcinoma in resection specimens.<ref name=pmid21252716>{{Cite journal | last1 = Travis | first1 = WD. | last2 = Brambilla | first2 = E. | last3 = Noguchi | first3 = M. | last4 = Nicholson | first4 = AG. | last5 = Geisinger | first5 = KR. | last6 = Yatabe | first6 = Y. | last7 = Beer | first7 = DG. | last8 = Powell | first8 = CA. | last9 = Riely | first9 = GJ. | title = International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. | journal = J Thorac Oncol | volume = 6 | issue = 2 | pages = 244-85 | month = Feb | year = 2011 | doi = 10.1097/JTO.0b013e318206a221 | PMID = 21252716 }}</ref> | ||
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===Images=== | ===Images=== | ||
<gallery> | |||
Image: Atypical adenomatous hyperplasia -- low mag.jpg | AAH - low mag. (WC) | |||
Image: Atypical adenomatous hyperplasia -- intermed mag.jpg | AAH - intermed. mag. (WC) | |||
Image: Atypical adenomatous hyperplasia - alt -- high mag.jpg | AAH - high mag. (WC) | |||
Image: Atypical adenomatous hyperplasia -- very high mag.jpg | AAH - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://www.nature.com/modpathol/journal/v20/n9/fig_tab/3800929f1.html#figure-title AAH (nature.com)].<ref name=pmid17618248/> | *[http://www.nature.com/modpathol/journal/v20/n9/fig_tab/3800929f1.html#figure-title AAH (nature.com)].<ref name=pmid17618248/> | ||
*[http://www.jthoracdis.com/article/viewFile/1518/html/9359 AAH (jthoracdis.com)].<ref>{{Cite journal | last1 = Davidson | first1 = MR. | last2 = Gazdar | first2 = AF. | last3 = Clarke | first3 = BE. | title = The pivotal role of pathology in the management of lung cancer. | journal = J Thorac Dis | volume = 5 | issue = Suppl 5 | pages = S463-S478 | month = Oct | year = 2013 | doi = 10.3978/j.issn.2072-1439.2013.08.43 | PMID = 24163740 }}</ref> | *[http://www.jthoracdis.com/article/viewFile/1518/html/9359 AAH (jthoracdis.com)].<ref>{{Cite journal | last1 = Davidson | first1 = MR. | last2 = Gazdar | first2 = AF. | last3 = Clarke | first3 = BE. | title = The pivotal role of pathology in the management of lung cancer. | journal = J Thorac Dis | volume = 5 | issue = Suppl 5 | pages = S463-S478 | month = Oct | year = 2013 | doi = 10.3978/j.issn.2072-1439.2013.08.43 | PMID = 24163740 }}</ref> | ||