Difference between revisions of "Atypical adenomatous hyperplasia of the lung"

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#redirect [[Lung_tumours#Atypical_alveolar_hyperplasia]]
'''Atypical alveolar hyperplasia of the lung''' is considered the precursor of [[lung adenocarcinoma]]. It is typically found beside lung adenocarcinoma in resection specimens.<ref name=pmid21252716>{{Cite journal  | last1 = Travis | first1 = WD. | last2 = Brambilla | first2 = E. | last3 = Noguchi | first3 = M. | last4 = Nicholson | first4 = AG. | last5 = Geisinger | first5 = KR. | last6 = Yatabe | first6 = Y. | last7 = Beer | first7 = DG. | last8 = Powell | first8 = CA. | last9 = Riely | first9 = GJ. | title = International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. | journal = J Thorac Oncol | volume = 6 | issue = 2 | pages = 244-85 | month = Feb | year = 2011 | doi = 10.1097/JTO.0b013e318206a221 | PMID = 21252716 }}</ref>
 
==General==
*Generally considered the precursor lesion to ''adenocarcinoma in situ''.<ref name=pmid17618248>{{Cite journal  | last1 = Sakuma | first1 = Y. | last2 = Matsukuma | first2 = S. | last3 = Yoshihara | first3 = M. | last4 = Nakamura | first4 = Y. | last5 = Nakayama | first5 = H. | last6 = Kameda | first6 = Y. | last7 = Tsuchiya | first7 = E. | last8 = Miyagi | first8 = Y. | title = Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung. | journal = Mod Pathol | volume = 20 | issue = 9 | pages = 967-73 | month = Sep | year = 2007 | doi = 10.1038/modpathol.3800929 | PMID = 17618248 }}</ref>
*Typically an incidental finding, i.e. asymptomatic.<ref name=Ref_WMSP114>{{Ref WMSP|114}}</ref>
 
==Microscopic==
Features:<ref name=Ref_WMSP114>{{Ref WMSP|114}}</ref>
*Enlarged alveolar lining cells with:
**Hobnail morphology - free (luminal) surface area > attached/basal surface area.
**Hyperchromasia.
**Spaces are typically seen between the cells.<ref>{{Cite journal  | last1 = Travis | first1 = WD. | last2 = Brambilla | first2 = E. | last3 = Noguchi | first3 = M. | last4 = Nicholson | first4 = AG. | last5 = Geisinger | first5 = KR. | last6 = Yatabe | first6 = Y. | last7 = Beer | first7 = DG. | last8 = Powell | first8 = CA. | last9 = Riely | first9 = GJ. | title = International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. | journal = J Thorac Oncol | volume = 6 | issue = 2 | pages = 244-85 | month = Feb | year = 2011 | doi = 10.1097/JTO.0b013e318206a221 | PMID = 21252716 }}</ref>
*Limited extent:
**<5 mm. †
 
DDx:
*Adenocarcinoma in situ.
*[[Lung adenocarcinoma]].
 
Note:
*  † [[Diagnostic size cutoff]].
 
===Images===
*[http://www.nature.com/modpathol/journal/v20/n9/fig_tab/3800929f1.html#figure-title AAH (nature.com)].<ref name=pmid17618248/>
 
==See also==
*[[Lung tumours]].
 
==References==
{{Reflist|2}}
 
[[Category:Lung tumours]]
[[Category:Diagnosis]]

Revision as of 18:35, 8 April 2014

Atypical alveolar hyperplasia of the lung is considered the precursor of lung adenocarcinoma. It is typically found beside lung adenocarcinoma in resection specimens.[1]

General

  • Generally considered the precursor lesion to adenocarcinoma in situ.[2]
  • Typically an incidental finding, i.e. asymptomatic.[3]

Microscopic

Features:[3]

  • Enlarged alveolar lining cells with:
    • Hobnail morphology - free (luminal) surface area > attached/basal surface area.
    • Hyperchromasia.
    • Spaces are typically seen between the cells.[4]
  • Limited extent:
    • <5 mm. †

DDx:

Note:

Images

See also

References

  1. ↑ Travis, WD.; Brambilla, E.; Noguchi, M.; Nicholson, AG.; Geisinger, KR.; Yatabe, Y.; Beer, DG.; Powell, CA. et al. (Feb 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.". J Thorac Oncol 6 (2): 244-85. doi:10.1097/JTO.0b013e318206a221. PMID 21252716.
  2. ↑ 2.0 2.1 Sakuma, Y.; Matsukuma, S.; Yoshihara, M.; Nakamura, Y.; Nakayama, H.; Kameda, Y.; Tsuchiya, E.; Miyagi, Y. (Sep 2007). "Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung.". Mod Pathol 20 (9): 967-73. doi:10.1038/modpathol.3800929. PMID 17618248.
  3. ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 114. ISBN 978-0781765275.
  4. ↑ Travis, WD.; Brambilla, E.; Noguchi, M.; Nicholson, AG.; Geisinger, KR.; Yatabe, Y.; Beer, DG.; Powell, CA. et al. (Feb 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.". J Thorac Oncol 6 (2): 244-85. doi:10.1097/JTO.0b013e318206a221. PMID 21252716.
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