48,470
edits
Difference between revisions of "Atrophy of the prostate gland"
Jump to navigation
Jump to search
Atrophy of the prostate gland (view source)
Revision as of 14:50, 4 August 2022
, 14:50, 4 August 2022no edit summary
(split) |
|||
| (14 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Atrophic prostatic glands -- intermed mag.jpg | |||
| Width = | |||
| Caption = Atrophic prostatic glands. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = glands typically have a jagged edges/prows (in cancer the glands tend to have round edges), gland density is usually lower than in prostate carcinoma (glands are not back-to-back), nuclei small & hyperchromatic, scant cytoplasm | |||
| Subtypes = | |||
| LMDDx = [[prostate carcinoma]] - esp. [[atrophic prostate carcinoma]], [[atypical small acinar proliferation]] | |||
| Stains = | |||
| IHC = [[AMACR]] -ve, [[p63]] +ve (basal cells), [[CK34betaE12]] +ve (basal cells) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[prostate gland]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = none | |||
| Prevalence = very common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = none | |||
}} | |||
'''Atrophy of the prostate gland''', also '''prostatic atrophy''', is a common change in the [[prostate gland]]. | '''Atrophy of the prostate gland''', also '''prostatic atrophy''', is a common change in the [[prostate gland]]. | ||
==General== | |||
*Considered to be the most common mimicker of [[prostate carcinoma]].<ref name=pmid18408595>{{Cite journal | last1 = Wang | first1 = W. | last2 = Sun | first2 = X. | last3 = Epstein | first3 = JI. | title = Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study. | journal = Am J Surg Pathol | volume = 32 | issue = 6 | pages = 851-7 | month = Jun | year = 2008 | doi = 10.1097/PAS.0b013e31815a0508 | PMID = 18408595 }}</ref> | |||
*Small glands - may mimic [[Gleason score|Gleason pattern]] 3. | |||
*Inflammatory atrophy seems to be related to [[HGPIN]] and [[prostate cancer]];<ref name=pmid10595928>{{Cite journal | last1 = De Marzo | first1 = AM. | last2 = Marchi | first2 = VL. | last3 = Epstein | first3 = JI. | last4 = Nelson | first4 = WG. | title = Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. | journal = Am J Pathol | volume = 155 | issue = 6 | pages = 1985-92 | month = Dec | year = 1999 | doi = 10.1016/S0002-9440(10)65517-4 | PMID = 10595928 }}</ref> however, the epidemiology is not compelling that this is a significant (clinical) association.<ref name=pmid24129226>{{Cite journal | last1 = Celma | first1 = A. | last2 = Servián | first2 = P. | last3 = Planas | first3 = J. | last4 = Placer | first4 = J. | last5 = Quilez | first5 = MT. | last6 = Arbós | first6 = MA. | last7 = de Torres | first7 = I. | last8 = Morote | first8 = J. | title = Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy. | journal = Actas Urol Esp | volume = 38 | issue = 2 | pages = 122-126 | month = Mar | year = 2014 | doi = 10.1016/j.acuro.2013.04.008 | PMID = 24129226 }}</ref> | |||
===Classification=== | |||
It can be classified into:<ref name=pmid20815946>{{Cite journal | last1 = Billis | first1 = A. | title = Prostatic atrophy. Clinicopathological significance. | journal = Int Braz J Urol | volume = 36 | issue = 4 | pages = 401-9 | month = | year = | doi = | PMID = 20815946 }}</ref> | |||
#Focal prostatic atrophy. | |||
#Diffuse prostatic atrophy. | |||
= | Focal atrophy can be subclassified as:<ref name=pmid20815946/> | ||
#Partial. | |||
#Complete. | |||
#Combined. | |||
==Microscopic== | ==Microscopic== | ||
| Line 27: | Line 66: | ||
DDx: | DDx: | ||
*[[Atrophic prostate carcinoma]]. | *[[Atrophic prostate carcinoma]]. | ||
*[[Atypical small acinar proliferation]]. | |||
*[[Prostate carcinoma]] - focal, low grade. | |||
===Atrophy versus cancer=== | ===Atrophy versus cancer=== | ||
| Line 58: | Line 99: | ||
|yes - eosinophilic <br>or blue | |yes - eosinophilic <br>or blue | ||
|} | |} | ||
===Images=== | |||
<gallery> | |||
Image: Atrophic prostatic glands -- low mag.jpg | APG - low mag. (WC) | |||
Image: Atrophic prostatic glands -- intermed mag.jpg | APG - intermed. mag. (WC) | |||
Image: Atrophic prostatic glands -- high mag.jpg | APG - high mag. (WC) | |||
Image: Atrophic prostatic glands -- very high mag.jpg | APG - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://webpathology.com/image.asp?case=16&n=7 Atrophy (webpathology.com)]. | |||
*[http://webpathology.com/image.asp?case=16&n=5 Partial atrophy (webpathology.com)]. | |||
*[http://webpathology.com/image.asp?case=16&n=6 Sclerotic atrophy (webpathology.com)]. | |||
==IHC== | |||
*Classically like normal prostate (AMACR -ve, p63 +ve, CK34betaE12 +ve). | |||
**May be negative for basal cell markers, i.e. p63 and CK34betaE12.<ref name=pmid18408595>{{cite journal |author=Wang W, Sun X, Epstein JI |title=Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study |journal=Am. J. Surg. Pathol. |volume=32 |issue=6 |pages=851–7 |year=2008 |month=June |pmid=18408595 |doi=10.1097/PAS.0b013e31815a0508 |url=}}</ref> | |||
==Sign out== | ==Sign out== | ||
Generally, this finding is ''not'' reported; it is considered a normal finding. | Generally, this finding is ''not'' reported; it is considered a normal finding. | ||
<pre> | |||
Left Apex: | |||
- Benign prostate tissue with glandular atrophy. | |||
</pre> | |||
===Micro=== | |||
The core shows rare, spaced, atrophic appearing glands, mostly with a wavy border and a decreased quantity of cytoplasm. Prominent nucleoli and significant nuclear enlargement are not identified. | |||
There are none of the following: mitoses, adjacent PIN, suspicious luminal material, nuclear hyperchromasia. | |||
==See also== | ==See also== | ||