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Difference between revisions of "Angiomatoid fibrous histiocytoma"
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Angiomatoid fibrous histiocytoma (view source)
Revision as of 02:53, 22 June 2014
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'''Angiomatoid fibrous histiocytoma''' is a rare [[soft tissue lesion]] that is typically seen in children and young adults. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Angiomatoid_fibrous_histiocytoma_-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Angiomatoid fibrous histiocytoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = cystic spaces with blood +/- histiocytic appearance; inflammation (lymphocytes around periphery of lesion); hemorrhage | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = CD68 +ve, CD57 +ve, desmin +ve (focal), vimentin +ve | |||
| EM = | |||
| Molecular = t(12;16) FUS/ATF1, t(12;22) EWS/ATF1, others | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[soft tissue lesions|soft tissue]] - usu. extremities | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = children, young adults | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usually good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = complete excision | |||
}} | |||
'''Angiomatoid fibrous histiocytoma''', abbreviated '''AFH''', is a rare [[soft tissue lesion]] that is typically seen in children and young adults. | |||
==General== | ==General== | ||
*Rarely metastasizes. | *Rarely metastasizes. | ||
*Children & young adults. | *Children & young adults. | ||
*Should be completely excised. | |||
==Gross== | |||
*Usu. soft tissue of the extremities.{{fact}} | |||
==Microscopic== | ==Microscopic== | ||
| Line 19: | Line 54: | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image: Angiomatoid fibrous histiocytoma - low mag.jpg | AFH - low mag. | ||
Image: | Image: Angiomatoid fibrous histiocytoma - intermed mag.jpg | AFH - intermed. mag. | ||
Image: Angiomatoid fibrous histiocytoma - high mag.jpg | AFH - high mag. | |||
Image: Angiomatoid fibrous histiocytoma - very high mag.jpg | AFH - very high mag. | |||
Image: Angiomatoid fibrous histiocytoma - intermed mag - 2.jpg | AFH - intermed. mag. | |||
Image: Angiomatoid fibrous histiocytoma - high mag - 2.jpg | AFH - high mag. | |||
Image: Angiomatoid fibrous histiocytoma - very high mag - 2.jpg | AFH - very high mag. | |||
</gallery> | </gallery> | ||
www: | www: | ||
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*CD68 +ve. | *CD68 +ve. | ||
*CD57 +ve. | *CD57 +ve. | ||
*Desmin +ve. | *Desmin +ve (focal). | ||
*Vimentin +ve. | *Vimentin +ve. | ||