Androgen receptor
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| Androgen receptor | |
|---|---|
| Immunostain in short | |
| Normal staining pattern | nuclear |
| Positive | salivary duct carcinoma, Brenner tumour, apocrine carcinoma of the breast, prostate carcinoma (most cases) |
Androgen receptor, abbreviated AR, is receptor activated by androgens (testosterone, dihydrotestosterone).
Tumours with AR
- Salivary duct carcinoma +ve ~90% of cases.[1]
- Ovarian Brenner tumour.[2]
- Apocrine carcinoma of the breast - usu. smaller tumours.[3]
See also
References
- ↑ Fan, CY.; Wang, J.; Barnes, EL. (Apr 2000). "Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature.". Am J Surg Pathol 24 (4): 579-86. PMID 10757407.
- ↑ Kuhn, E.; Ayhan, A.; Shih, IeM.; Seidman, JD.; Kurman, RJ. (Dec 2013). "Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium.". Eur J Cancer 49 (18): 3839-49. doi:10.1016/j.ejca.2013.08.011. PMID 24012099.
- ↑ Honma, N.; Takubo, K.; Akiyama, F.; Sawabe, M.; Arai, T.; Younes, M.; Kasumi, F.; Sakamoto, G. (Aug 2005). "Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast.". Histopathology 47 (2): 195-201. doi:10.1111/j.1365-2559.2005.02181.x. PMID 16045781.