Difference between revisions of "Anal squamous cell carcinoma"
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'''Anal squamous cell carcinoma''' is a type of [[anal cancer]]. | |||
It is also known as '''anal squamous carcinoma''' and '''squamous cell carcinoma of the anus'''. | |||
==General== | |||
*Most common form of anal cancer. | |||
Risk factors:<ref name=pmid23806153>{{Cite journal | last1 = Kutlubay | first1 = Z. | last2 = Engin | first2 = B. | last3 = Zara | first3 = T. | last4 = Tüzün | first4 = Y. | title = Anogenital malignancies and premalignancies: Facts and controversies. | journal = Clin Dermatol | volume = 31 | issue = 4 | pages = 362-73 | month = | year = | doi = 10.1016/j.clindermatol.2013.01.003 | PMID = 23806153 }}</ref> | |||
*Men who have sex with men. | |||
*Immunosuppressed. | |||
*[[HIV]] infection. | |||
==Microscopic== | |||
Features: | |||
*See ''[[squamous cell carcinoma]]''. | |||
<gallery> | |||
Image:Anus SquamousCellCarcinoma SCC NonKeratinizing AIA SCCIS CTR.jpg|Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB) | |||
Image:Anus SquamousCellCarcinoma SCC NonKeratinizing MP CTR.jpg|Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB) | |||
Image:Anus SquamousCellCarcinoma SCC NonKeratinizing MP4 CTR.jpg|Anus Squamous Cell Carcinoma (Non Keratinizing or shall we say poorly keratinizing as there are squamatized nests focally at high power) - (SKB) | |||
</gallery> | |||
DDx: | |||
*[[Anal gland adenocarcinoma]]. | |||
*Poorly differentiated [[rectal adenocarcinoma]]. | |||
==IHC== | |||
*p16 +ve.<ref name=pmid23105122/> | |||
*CDX2 -ve/+ve. | |||
**May be useful to differentiate from [[vulva]] and [[penis]].<ref name=pmid23105122>{{Cite journal | last1 = Gunia | first1 = S. | last2 = Koch | first2 = S. | last3 = May | first3 = M. | title = Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis? | journal = J Clin Pathol | volume = 66 | issue = 2 | pages = 109-12 | month = Feb | year = 2013 | doi = 10.1136/jclinpath-2012-201138 | PMID = 23105122 }}</ref> | |||
==Sign out== | |||
<pre> | |||
RECTUM, DISTAL, BIOPSY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA. | |||
</pre> | |||
==See also== | |||
*[[Anus]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Anus]] | |||
Revision as of 17:56, 19 March 2015
Anal squamous cell carcinoma is a type of anal cancer.
It is also known as anal squamous carcinoma and squamous cell carcinoma of the anus.
General
- Most common form of anal cancer.
Risk factors:[1]
- Men who have sex with men.
- Immunosuppressed.
- HIV infection.
Microscopic
Features:
Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)
Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)
Anus Squamous Cell Carcinoma (Non Keratinizing or shall we say poorly keratinizing as there are squamatized nests focally at high power) - (SKB)
DDx:
- Anal gland adenocarcinoma.
- Poorly differentiated rectal adenocarcinoma.
IHC
Sign out
RECTUM, DISTAL, BIOPSY: - INVASIVE SQUAMOUS CELL CARCINOMA.
See also
- Anus.
References
- ↑ Kutlubay, Z.; Engin, B.; Zara, T.; Tüzün, Y.. "Anogenital malignancies and premalignancies: Facts and controversies.". Clin Dermatol 31 (4): 362-73. doi:10.1016/j.clindermatol.2013.01.003. PMID 23806153.
- ↑ 2.0 2.1 Gunia, S.; Koch, S.; May, M. (Feb 2013). "Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis?". J Clin Pathol 66 (2): 109-12. doi:10.1136/jclinpath-2012-201138. PMID 23105122.