Amnion nodosum

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Amnion nodosum is an uncommon benign placental pathology.

General

  • Associated with (long-standing) oligohydramnios.[1]
  • Should be separated from squamous metaplasia of amnion.

Gross

Features:[2]

  • Yellow nodules ~ 1-5 mm.
    • Some think they are white.[3]

DDx:

Images:

Microscopic

Features:[2]

  • Stratified squamous epithelium - non-keratinizing or minimal keratin.
  • Amorphous acidophilic (pink) debris.

Note:

  • Normal amnion = simple epithelium.

Images:

See also

References

  1. URL: http://library.med.utah.edu/WebPath/PLACHTML/PLAC042.html. Accessed on: 12 January 2011.
  2. 2.0 2.1 2.2 2.3 Adeniran, AJ.; Stanek, J. (Dec 2007). "Amnion nodosum revisited: clinicopathologic and placental correlations.". Arch Pathol Lab Med 131 (12): 1829-33. doi:10.1043/1543-2165(2007)131[1829:ANRCAP]2.0.CO;2. PMID 18081444.
  3. CS. 7 February 2011.