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Difference between revisions of "Adrenal cortical adenoma"
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| LMDDx = adrenal cortical nodule, [[adrenal cortical hyperplasia]], [[adrenal cortical carcinoma]] | | LMDDx = adrenal cortical nodule, [[adrenal cortical hyperplasia]], [[adrenal cortical carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = [[calretinin]], inhibin | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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#High mitotic rate; >5/50 HPF (@ 40X obj.) - definition suffers from [[HPFitis]]. | #High mitotic rate; >5/50 HPF (@ 40X obj.) - definition suffers from [[HPFitis]]. | ||
#Atypical mitoses. | #Atypical mitoses. | ||
#Cleared cytoplasm in | #Cleared cytoplasm in <= 25% of tumour cells. | ||
#Sheeting (diffuse architecture) in >= 1/3 of tumour cells. | #Sheeting (diffuse architecture) in >= 1/3 of tumour cells. | ||
#Necrosis in nests. | #Necrosis in nests. | ||
| Line 97: | Line 97: | ||
Image: Adrenal LipoAdenoma MP PA.JPG|Adrenal cortical adenoma with fat - "lipoadenoma" (SKB) | Image: Adrenal LipoAdenoma MP PA.JPG|Adrenal cortical adenoma with fat - "lipoadenoma" (SKB) | ||
</gallery> | </gallery> | ||
==IHC== | |||
Features:<ref name=pmid11893039>{{cite journal |authors=Jorda M, De MB, Nadji M |title=Calretinin and inhibin are useful in separating adrenocortical neoplasms from pheochromocytomas |journal=Appl. Immunohistochem. Mol. Morphol. |volume=10 |issue=1 |pages=67–70 |date=March 2002 |pmid=11893039 |doi=10.1097/00129039-200203000-00012 |url=}}</ref> | |||
*[[Calretinin]] +ve. | |||
*Inhibin +ve. | |||
Note: | |||
*Calretinin and inhibin in combination are useful for adrenal versus [[pheochromocytoma]].<ref name=pmid11893039/> | |||
==Sign out== | ==Sign out== | ||
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Adrenal Gland, Right, Adrenalectomy: | Adrenal Gland, Right, Adrenalectomy: | ||
- Adrenal cortical adenoma. | - Adrenal cortical adenoma. | ||
</pre> | |||
===Microscopic=== | |||
<pre> | |||
The sections show a benign adrenal gland with an expanded cortex. | |||
Clearing of the cytoplasm is present in the cortex. | |||
None of the following are present in the cortex: | |||
High nuclear grade, high mitotic rate (mitotic activity 1/50 HPF, | |||
where 1 HPF~=0.2376 mm*mm), atypical mitoses, sheeting, necrosis, | |||
sinusoidal invasion, venous invasion, capsular invasion. | |||
</pre> | </pre> | ||