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Difference between revisions of "Adenoid cystic carcinoma"
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| Width = | | Width = | ||
| Caption = Adenoid cystic carcinoma. [[H&E stain]]. | | Caption = Adenoid cystic carcinoma. [[H&E stain]]. | ||
| Micro = cribriform architecture (other patterns: solid, cords, (bilayered) tubules), cystic spaces filled with basophilic material, scant cytoplasm in most cells, nucleus - small, hyaline stroma | | Micro = [[cribriform architecture]] (other patterns: solid, cords, (bilayered) tubules), cystic spaces filled with basophilic material, scant cytoplasm in most cells, nucleus - small, hyaline stroma | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[pleomorphic adenoma]] | | LMDDx = [[pleomorphic adenoma]], [[epithelial-myoepithelial carcinoma]], [[intraductal carcinoma of the salivary gland|intraductal carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 14: | Line 14: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[salivary gland]], [[breast]], [[lung]] | | Site = [[salivary gland]], [[breast]], [[lung]], [[skin]], [[trachea]], others | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 20: | Line 20: | ||
| Signs = mass | | Signs = mass | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = relatively common malignant salivary gland tumour | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Line 27: | Line 27: | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = surgical excision | |||
}} | }} | ||
'''Adenoid cystic carcinoma''', abbreviated '''AdCC'', is a malignant tumour commonly seen in the [[salivary gland]]. | '''Adenoid cystic carcinoma''', abbreviated '''AdCC''', is a malignant tumour commonly seen in the [[salivary gland]]. | ||
==General== | ==General== | ||
*Common malignant neoplasm of salivary gland. | *Common malignant neoplasm of salivary gland.<ref name=pmid8949764>{{Cite journal | last1 = Krüll | first1 = A. | last2 = Schwarz | first2 = R. | last3 = Engenhart | first3 = R. | last4 = Huber | first4 = P. | last5 = Lessel | first5 = A. | last6 = Koppe | first6 = H. | last7 = Favre | first7 = A. | last8 = Breteau | first8 = N. | last9 = Auberger | first9 = T. | title = European results in neutron therapy of malignant salivary gland tumors. | journal = Bull Cancer Radiother | volume = 83 Suppl | issue = | pages = 125-9s | month = | year = 1996 | doi = | PMID = 8949764 }}</ref> | ||
*May occur in the skin.<ref name=pmid3010759>{{Cite journal | last1 = Wick | first1 = MR. | last2 = Swanson | first2 = PE. | title = Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma. | journal = Am J Dermatopathol | volume = 8 | issue = 1 | pages = 2-13 | month = Feb | year = 1986 | doi = | PMID = 3010759 }}</ref> | |||
*AKA ''cylindroma''.<ref>Chest. May 1957. Vol. 31. No. 5. PP. 493-511. [http://www.chestjournal.org/content/31/5/493.abstract http://www.chestjournal.org/content/31/5/493.abstract]</ref> | *AKA ''cylindroma''.<ref>Chest. May 1957. Vol. 31. No. 5. PP. 493-511. [http://www.chestjournal.org/content/31/5/493.abstract http://www.chestjournal.org/content/31/5/493.abstract]</ref> | ||
**Should ''not'' be confused with ''[[dermal cylindroma]]'' (a benign skin tumour). | **Should ''not'' be confused with ''[[dermal cylindroma]]'' (a benign skin tumour). | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Cribriform architecture ''or'' pseudoglandular spaces (classic pattern) - '''important feature'''. | *[[Cribriform architecture]] ''or'' pseudoglandular spaces (classic pattern) - '''important feature'''. | ||
**Other patterns: solid, cords, (bilayered) tubules. | **Other patterns: solid, cords, (bilayered) tubules. | ||
**Cystic spaces filled with basophilic material (that is PAS +ve) - '''key feature'''. | **Cystic spaces filled with basophilic material (that is PAS +ve) - '''key feature'''. | ||
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**Basaloid [[squamous cell carcinoma]]. | **Basaloid [[squamous cell carcinoma]]. | ||
**[[Basal cell carcinoma]] (BCC). | **[[Basal cell carcinoma]] (BCC). | ||
*[[Perineural invasion]] is usually present. | |||
**If it is ''not'' one should consider other diagnoses. | |||
DDx: | DDx: | ||
*[[Pleomorphic adenoma]], esp. if encapsulated. | *[[Pleomorphic adenoma]], esp. if encapsulated. | ||
*[[Epithelial-myoepithelial carcinoma]] - esp. for AdCC tubular variant. | |||
*[[Human papillomavirus-related multiphenotypic sinonasal carcinoma]] (previously known as [[human papillomavirus-related carcinoma with adenoid cystic-like features]]). | |||
*[[Intraductal carcinoma of the salivary gland]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Adenoid cystic carcinoma - low mag.jpg | AdCC - low mag. (WC/Nephron) | Image:Adenoid cystic carcinoma - low mag.jpg | AdCC - low mag. (WC/Nephron) | ||
Image:Adenoid_cystic_carcinoma_-_intermed_mag.jpg | AdCC - intermed. mag. (WC/Nephron) | Image:Adenoid_cystic_carcinoma_-_intermed_mag.jpg | AdCC - intermed. mag. (WC/Nephron) | ||
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Image:Adenoid cystic carcinoma - very high mag.jpg | AdCC - very high mag. (WC/Nephron) | Image:Adenoid cystic carcinoma - very high mag.jpg | AdCC - very high mag. (WC/Nephron) | ||
Image:Adenoid_cystic_carcinoma_-a-_very_high_mag.jpg | AdCC - very high mag. (WC/Nephron) | Image:Adenoid_cystic_carcinoma_-a-_very_high_mag.jpg | AdCC - very high mag. (WC/Nephron) | ||
File:Breast_AdenoidCysticCarcinoma_SolidType_14BR***.jpg | AdCC of breast - solid type (WC/Sarahkayb) | |||
</gallery> | |||
<gallery> | |||
Image: Adenoid cystic carcinoma of the trachea -- low mag.jpg | AdCC [[trachea]] - low mag. | |||
Image: Adenoid cystic carcinoma of the trachea -- intermed mag.jpg | AdCC trachea - intermed. mag. | |||
Image: Adenoid cystic carcinoma of the trachea -- high mag.jpg | AdCC trachea - high mag. | |||
Image: Adenoid cystic carcinoma of the trachea -- very high mag.jpg | AdCC trachea - very high mag. | |||
Image: Adenoid cystic carcinoma of the trachea - alt -- very high mag.jpg | AdCC trachea - very high mag. | |||
</gallery> | </gallery> | ||
===Grading=== | ===Grading=== | ||
Based on solid component: | Based on solid component: | ||
| Line 82: | Line 93: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid19360297>{{Cite journal | last1 = Sequeiros-Santiago | first1 = G. | last2 = García-Carracedo | first2 = D. | last3 = Fresno | first3 = MF. | last4 = Suarez | first4 = C. | last5 = Rodrigo | first5 = JP. | last6 = Gonzalez | first6 = MV. | title = Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. | journal = Oncol Rep | volume = 21 | issue = 5 | pages = 1215-22 | month = May | year = 2009 | doi = | PMID = 19360297 }}</ref> | Features:<ref name=pmid19360297>{{Cite journal | last1 = Sequeiros-Santiago | first1 = G. | last2 = García-Carracedo | first2 = D. | last3 = Fresno | first3 = MF. | last4 = Suarez | first4 = C. | last5 = Rodrigo | first5 = JP. | last6 = Gonzalez | first6 = MV. | title = Oncogene amplification pattern in adenoid cystic carcinoma of the salivary glands. | journal = Oncol Rep | volume = 21 | issue = 5 | pages = 1215-22 | month = May | year = 2009 | doi = | PMID = 19360297 }}</ref> | ||
*CD117 +ve. | *[[CD117]] +ve. | ||
*Cyclin D1 +ve. | *Cyclin D1 +ve/-ve. | ||
Others:<ref name=pmid24037641>{{Cite journal | last1 = Thompson | first1 = LD. | last2 = Penner | first2 = C. | last3 = Ho | first3 = NJ. | last4 = Foss | first4 = RD. | last5 = Miettinen | first5 = M. | last6 = Wieneke | first6 = JA. | last7 = Moskaluk | first7 = CA. | last8 = Stelow | first8 = EB. | title = Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases. | journal = Head Neck Pathol | volume = | issue = | pages = | month = Sep | year = 2013 | doi = 10.1007/s12105-013-0487-3 | PMID = 24037641 }}</ref> | |||
*[[CK7]] +ve. | |||
*[[Pankeratin]] +ve. | |||
*[[p63]] +ve. | |||
*Calponin +ve. | |||
*S-100 +ve. | |||
Note: | |||
*Myoepithelial markers (e.g. calponin, actin) +ve. | *Myoepithelial markers (e.g. calponin, actin) +ve. | ||
**Typically -ve in PLGA. | **Typically -ve in [[PLGA]]. | ||
==Molecular== | ==Molecular== | ||
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==See also== | ==See also== | ||
*[[Salivary glands]]. | *[[Salivary glands]]. | ||
*[[Adenoid cystic carcinoma of the breast]]. | |||
*[[Adenoid cystic/basal cell carcinoma of the prostate]]. | |||
*[[Head and neck pathology]]. | |||
*[[Head and neck cytopathology]]. | |||
==References== | ==References== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Head and neck pathology]] | [[Category:Head and neck pathology]] | ||
[[Category:Salivary gland]] | |||