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Difference between revisions of "Adenocarcinoma of the uterine cervix"
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Adenocarcinoma of the uterine cervix (view source)
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It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''. | It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''. | ||
Very well-differentiated adenocarcinoma of the cervix is covered in ''[[minimal deviation adenocarcinoma of the uterine cervix]]''. | |||
==General== | ==General== | ||
*Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix. | *Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix. | ||
*Arises from the endocervical glands. | *Arises from the endocervical glands. | ||
*Usually [[HPV]] related. | |||
*Non-HPV related adenocarcinoma may be syndromic - [[Peutz-Jeghers syndrome]], [[Li-Fraumeni syndrome]].<ref name=pmid26457350>{{Cite journal | last1 = Karamurzin | first1 = YS. | last2 = Kiyokawa | first2 = T. | last3 = Parkash | first3 = V. | last4 = Jotwani | first4 = AR. | last5 = Patel | first5 = P. | last6 = Pike | first6 = MC. | last7 = Soslow | first7 = RA. | last8 = Park | first8 = KJ. | title = Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis. | journal = Am J Surg Pathol | volume = 39 | issue = 11 | pages = 1449-57 | month = Nov | year = 2015 | doi = 10.1097/PAS.0000000000000532 | PMID = 26457350 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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Image:Cervical_adenocarcinoma_-_intermed_mag.jpg | Cervical adenocarcinoma - intermed. mag. (WC) | Image:Cervical_adenocarcinoma_-_intermed_mag.jpg | Cervical adenocarcinoma - intermed. mag. (WC) | ||
Image:Cervical_adenocarcinoma_-_high_mag.jpg | Cervical adenocarcinoma - high mag. (WC) | Image:Cervical_adenocarcinoma_-_high_mag.jpg | Cervical adenocarcinoma - high mag. (WC) | ||
</gallery> | |||
<gallery> | |||
Image: Endocervical_adenocarcinoma_(1).jpg | Endocervical adenocarcinoma. (WC/KGH) | |||
Image: Endocervical_adenocarcinoma_(2).jpg | Endocervical adenocarcinoma. (WC/KGH) | |||
Image: Endocervical_adenocarcinoma_(3).jpg | Endocervical adenocarcinoma. (WC/KGH) | |||
Image: Endocervical_adenocarcinoma_(4).jpg | Endocervical adenocarcinoma. (WC/KGH) | |||
</gallery> | </gallery> | ||
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*Ki-67 -- high. | *Ki-67 -- high. | ||
Uterus vs. cervix:<ref> | Uterus vs. cervix:<ref name=pmid20335127>{{Cite journal | last1 = Hu | first1 = WW. | last2 = Tao | first2 = JH. | last3 = Li | first3 = GM. | last4 = Xu | first4 = X. | last5 = Yang | first5 = XM. | title = [Value of ER, VIM, CEA and p16 detection in the diagnosis and differential diagnosis of primary endocervical and endometrial adenocarcinomas]. | journal = Nan Fang Yi Ke Da Xue Xue Bao | volume = 30 | issue = 3 | pages = 526-8, 531 | month = Mar | year = 2010 | doi = | PMID = 20335127 }}</ref> | ||
*Cervix (typically): CEA +ve, p16 +ve. | *Cervix (typically): CEA +ve, p16 +ve. | ||
**ER -ve, PR -ve, vimentin -ve. | **[[ER]] -ve, PR -ve, vimentin -ve. | ||
*Uterus (typically): vimentin +ve, ER +ve, PR +ve. | *Uterus (typically): vimentin +ve, ER +ve, PR +ve. | ||
**CEA -ve, p16 -ve. | **CEA -ve, p16 -ve. | ||