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Difference between revisions of "Adenocarcinoma of the rete testis"
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Adenocarcinoma of the rete testis (view source)
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| LMDDx = [[adenomatous hyperplasia of the rete testis]], [[Sertoli cell tumour]], [[malignant mesothelioma]], metastasis | | LMDDx = [[adenomatous hyperplasia of the rete testis]], [[Sertoli cell tumour]], [[malignant mesothelioma]], metastasis | ||
| Stains = | | Stains = | ||
| IHC = EMA +ve, CK7 +ve, PSA -ve, calretinin -ve, CK5/6 -ve, PLAP -ve, AFP -ve, CD30 -ve | | IHC = EMA +ve, [[CK7]] +ve, PSA -ve, calretinin -ve, CK5/6 -ve, PLAP -ve, [[AFP]] -ve, CD30 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Gross = hilar mass | | Gross = hilar mass | ||
| Grossing = [[orchiectomy grossing]] | | Grossing = [[orchiectomy grossing]] | ||
| Site = [[testis]] - | | Site = [[paratesticular region]]/[[testis]] - see ''[[rete testis]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Adenocarcinoma of the rete testis''', also '''rete testis adenocarcinoma''', is a very rare [[malignant]] tumour of the [[testis]]. | '''Adenocarcinoma of the rete testis''', also '''rete testis adenocarcinoma''', is a very rare [[malignant]] tumour of the [[paratesticular region]]/[[testis]]. | ||
==General== | ==General== | ||
*Extremely rare<ref name=pmid6465420>{{Cite journal | last1 = Nochomovitz | first1 = LE. | last2 = Orenstein | first2 = JM. | title = Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates. | journal = Am J Surg Pathol | volume = 8 | issue = 8 | pages = 625-34 | month = Aug | year = 1984 | doi = | PMID = 6465420 }}</ref> - a few dozen cases in the world literature. | *Extremely rare<ref name=pmid6465420>{{Cite journal | last1 = Nochomovitz | first1 = LE. | last2 = Orenstein | first2 = JM. | title = Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates. | journal = Am J Surg Pathol | volume = 8 | issue = 8 | pages = 625-34 | month = Aug | year = 1984 | doi = | PMID = 6465420 }}</ref> - a few dozen cases in the world literature. | ||
*Typically older men (>60 years old), but reported in younger men with undescended testis.<ref name=pmid6465420/> | *Typically older men (>60 years old), but reported in younger men with undescended testis.<ref name=pmid6465420/> | ||
*Possible association | *Possible association with diethylstilbestrol - based on non-human data.<ref name=pmid3799821>{{Cite journal | last1 = Newbold | first1 = RR. | last2 = Bullock | first2 = BC. | last3 = McLachlan | first3 = JA. | title = Adenocarcinoma of the rete testis. Diethylstilbestrol-induced lesions of the mouse rete testis. | journal = Am J Pathol | volume = 125 | issue = 3 | pages = 625-8 | month = Dec | year = 1986 | doi = | PMID = 3799821 | PMC = 1888460 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888460/?page=1}}</ref> | ||
*Prognosis poor<ref name=pmid17853037>{{Cite journal | last1 = Sogni | first1 = F. | last2 = Monga | first2 = G. | last3 = Terrone | first3 = C. | last4 = Gontero | first4 = P. | title = Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas. | journal = Scand J Urol Nephrol | volume = 42 | issue = 1 | pages = 83-5 | month = | year = 2008 | doi = 10.1080/00365590701517608 | PMID = 17853037 }}</ref> - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.<ref name=pmid7571213>{{Cite journal | last1 = Sánchez-Chapado | first1 = M. | last2 = Angulo | first2 = JC. | last3 = Haas | first3 = GP. | title = Adenocarcinoma of the rete testis. | journal = Urology | volume = 46 | issue = 4 | pages = 468-75 | month = Oct | year = 1995 | doi = 10.1016/S0090-4295(99)80257-X | PMID = 7571213 }}</ref> | *Prognosis poor<ref name=pmid17853037>{{Cite journal | last1 = Sogni | first1 = F. | last2 = Monga | first2 = G. | last3 = Terrone | first3 = C. | last4 = Gontero | first4 = P. | title = Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas. | journal = Scand J Urol Nephrol | volume = 42 | issue = 1 | pages = 83-5 | month = | year = 2008 | doi = 10.1080/00365590701517608 | PMID = 17853037 }}</ref> - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.<ref name=pmid7571213>{{Cite journal | last1 = Sánchez-Chapado | first1 = M. | last2 = Angulo | first2 = JC. | last3 = Haas | first3 = GP. | title = Adenocarcinoma of the rete testis. | journal = Urology | volume = 46 | issue = 4 | pages = 468-75 | month = Oct | year = 1995 | doi = 10.1016/S0090-4295(99)80257-X | PMID = 7571213 }}</ref> | ||
Clinical: | Clinical: | ||
*[[Germ cell tumour]] serum markers (LDH, AFP, beta-hCG) typically normal. | *[[Germ cell tumour]] serum markers (LDH, AFP, beta-hCG) typically normal. | ||
==Gross== | ==Gross== | ||
| Line 72: | Line 72: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid23800084/> | Features:<ref name=pmid23800084/> | ||
*CK7 +ve. | *[[CK7]] +ve. | ||
*EMA +ve. | *[[EMA]] +ve. | ||
Others:<ref name=pmid23800084/> | Others:<ref name=pmid23800084/> | ||
*AFP -ve. | *[[AFP]] -ve. | ||
*CD30 -ve. | *CD30 -ve. | ||
*PLAP -ve. | *PLAP -ve. | ||
*CK5/6 -ve. | *CK5/6 -ve. | ||
*Calretinin -ve. | *Calretinin -ve. | ||
*PSA -ve. | *[[PSA]] -ve. | ||
==See also== | ==See also== | ||