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Difference between revisions of "Adenocarcinoma of the rete testis"
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Adenocarcinoma of the rete testis (view source)
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| Caption = Adenocarcinoma of the rete testis. [[H&E stain]]. | | Caption = Adenocarcinoma of the rete testis. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = atypical columnar or cuboidal cells, often with cigar-shaped nuclei; classically tubular or papillary architecture; transistion to normal appearing rete testis | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[adenomatous hyperplasia of the rete testis]], [[Sertoli cell tumour]], metastasis | | LMDDx = [[adenomatous hyperplasia of the rete testis]], [[Sertoli cell tumour]], [[malignant mesothelioma]], metastasis | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = EMA +ve, [[CK7]] +ve, PSA -ve, calretinin -ve, CK5/6 -ve, PLAP -ve, [[AFP]] -ve, CD30 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = [[orchiectomy grossing]] | | Gross = hilar mass | ||
| Grossing = [[orchiectomy grossing]] | |||
| Site = [[testis]] - | | Site = [[paratesticular region]]/[[testis]] - see ''[[rete testis]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 22: | Line 22: | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = extremely rare | | Prevalence = extremely rare | ||
| Bloodwork = | | Bloodwork = markers for GCT typically normal | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Adenocarcinoma of the rete testis''', also '''rete testis adenocarcinoma''', is a very rare [[malignant]] tumour of the [[testis]]. | '''Adenocarcinoma of the rete testis''', also '''rete testis adenocarcinoma''', is a very rare [[malignant]] tumour of the [[paratesticular region]]/[[testis]]. | ||
==General== | ==General== | ||
*Extremely rare<ref name=pmid6465420>{{Cite journal | last1 = Nochomovitz | first1 = LE. | last2 = Orenstein | first2 = JM. | title = Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates. | journal = Am J Surg Pathol | volume = 8 | issue = 8 | pages = 625-34 | month = Aug | year = 1984 | doi = | PMID = 6465420 }}</ref> - a few dozen cases in the world literature. | *Extremely rare<ref name=pmid6465420>{{Cite journal | last1 = Nochomovitz | first1 = LE. | last2 = Orenstein | first2 = JM. | title = Adenocarcinoma of the rete testis. Case report, ultrastructural observations, and clinicopathologic correlates. | journal = Am J Surg Pathol | volume = 8 | issue = 8 | pages = 625-34 | month = Aug | year = 1984 | doi = | PMID = 6465420 }}</ref> - a few dozen cases in the world literature. | ||
*Typically older men (>60 years old), but reported in younger men with undescended testis.<ref name=pmid6465420/> | *Typically older men (>60 years old), but reported in younger men with undescended testis.<ref name=pmid6465420/> | ||
*Possible association | *Possible association with diethylstilbestrol - based on non-human data.<ref name=pmid3799821>{{Cite journal | last1 = Newbold | first1 = RR. | last2 = Bullock | first2 = BC. | last3 = McLachlan | first3 = JA. | title = Adenocarcinoma of the rete testis. Diethylstilbestrol-induced lesions of the mouse rete testis. | journal = Am J Pathol | volume = 125 | issue = 3 | pages = 625-8 | month = Dec | year = 1986 | doi = | PMID = 3799821 | PMC = 1888460 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888460/?page=1}}</ref> | ||
*Prognosis poor<ref name=pmid17853037>{{Cite journal | last1 = Sogni | first1 = F. | last2 = Monga | first2 = G. | last3 = Terrone | first3 = C. | last4 = Gontero | first4 = P. | title = Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas. | journal = Scand J Urol Nephrol | volume = 42 | issue = 1 | pages = 83-5 | month = | year = 2008 | doi = 10.1080/00365590701517608 | PMID = 17853037 }}</ref> - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.<ref name=pmid7571213>{{Cite journal | last1 = Sánchez-Chapado | first1 = M. | last2 = Angulo | first2 = JC. | last3 = Haas | first3 = GP. | title = Adenocarcinoma of the rete testis. | journal = Urology | volume = 46 | issue = 4 | pages = 468-75 | month = Oct | year = 1995 | doi = 10.1016/S0090-4295(99)80257-X | PMID = 7571213 }}</ref> | *Prognosis poor<ref name=pmid17853037>{{Cite journal | last1 = Sogni | first1 = F. | last2 = Monga | first2 = G. | last3 = Terrone | first3 = C. | last4 = Gontero | first4 = P. | title = Primary adenocarcinoma of the rete testis: diagnostic problems and therapeutic dilemmas. | journal = Scand J Urol Nephrol | volume = 42 | issue = 1 | pages = 83-5 | month = | year = 2008 | doi = 10.1080/00365590701517608 | PMID = 17853037 }}</ref> - 3-year and 5-year disease-free survival approximately 50% and 15% respectively.<ref name=pmid7571213>{{Cite journal | last1 = Sánchez-Chapado | first1 = M. | last2 = Angulo | first2 = JC. | last3 = Haas | first3 = GP. | title = Adenocarcinoma of the rete testis. | journal = Urology | volume = 46 | issue = 4 | pages = 468-75 | month = Oct | year = 1995 | doi = 10.1016/S0090-4295(99)80257-X | PMID = 7571213 }}</ref> | ||
Clinical: | |||
*[[Germ cell tumour]] serum markers (LDH, AFP, beta-hCG) typically normal. | |||
==Gross== | ==Gross== | ||
| Line 45: | Line 48: | ||
*Adenocarcinoma: | *Adenocarcinoma: | ||
**Atypical columnar or cuboidal cells, often with cigar-shaped nuclei. | **Atypical columnar or cuboidal cells, often with cigar-shaped nuclei. | ||
** | **Classically tubular or papillary architecture.<ref name=pmid3799821/> | ||
*Transistion to normal appearing rete testis.<ref name=pmid6465420/> | *Transistion to normal appearing rete testis.<ref name=pmid6465420/> | ||
DDx: | DDx: | ||
*[[Adenomatous hyperplasia of the rete testis]]. | *[[Adenomatous hyperplasia of the rete testis]] - may be a concurrent pathology.<ref name=pmid23800084>{{Cite journal | last1 = Lin | first1 = XY. | last2 = Yu | first2 = JH. | last3 = Xu | first3 = HT. | last4 = Wang | first4 = L. | last5 = Fan | first5 = CF. | last6 = Liu | first6 = Y. | last7 = Wang | first7 = EH. | title = A case of adenocarcinoma of the rete testis accompanied by focal adenomatous hyperplasia. | journal = Diagn Pathol | volume = 8 | issue = | pages = 105 | month = | year = 2013 | doi = 10.1186/1746-1596-8-105 | PMID = 23800084 }}</ref> | ||
*[[Metastatic]] carcinoma involving the testis - usually [[prostate carcinoma|prostate]], kidney, or colon.<ref name=pmid18769334>{{Cite journal | last1 = Ulbright | first1 = TM. | last2 = Young | first2 = RH. | title = Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features. | journal = Am J Surg Pathol | volume = 32 | issue = 11 | pages = 1683-93 | month = Nov | year = 2008 | doi = 10.1097/PAS.0b013e3181788516 | PMID = 18769334 }}</ref> | *[[Metastatic]] carcinoma involving the testis - usually [[prostate carcinoma|prostate]], kidney, or colon.<ref name=pmid18769334>{{Cite journal | last1 = Ulbright | first1 = TM. | last2 = Young | first2 = RH. | title = Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features. | journal = Am J Surg Pathol | volume = 32 | issue = 11 | pages = 1683-93 | month = Nov | year = 2008 | doi = 10.1097/PAS.0b013e3181788516 | PMID = 18769334 }}</ref> | ||
*[[Sertoli cell tumour]]. | *[[Sertoli cell tumour]]. | ||
| Line 66: | Line 69: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881943/figure/f2-ol-07-02-0455/ ART (nih.gov)].<ref name=pmid24396468>{{Cite journal | last1 = Tian | first1 = Y. | last2 = Yao | first2 = W. | last3 = Yang | first3 = L. | last4 = Wang | first4 = J. | last5 = Wazir | first5 = R. | last6 = Wang | first6 = K. | title = Primary adenocarcinoma of the rete testis: A case report and review of the literature. | journal = Oncol Lett | volume = 7 | issue = 2 | pages = 455-457 | month = Feb | year = 2014 | doi = 10.3892/ol.2013.1708 | PMID = 24396468 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881943/figure/f2-ol-07-02-0455/ ART (nih.gov)].<ref name=pmid24396468>{{Cite journal | last1 = Tian | first1 = Y. | last2 = Yao | first2 = W. | last3 = Yang | first3 = L. | last4 = Wang | first4 = J. | last5 = Wazir | first5 = R. | last6 = Wang | first6 = K. | title = Primary adenocarcinoma of the rete testis: A case report and review of the literature. | journal = Oncol Lett | volume = 7 | issue = 2 | pages = 455-457 | month = Feb | year = 2014 | doi = 10.3892/ol.2013.1708 | PMID = 24396468 }}</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350189/figure/fig3/ ART (nih.gov)].<ref>{{Cite journal | last1 = Wu | first1 = CA. | last2 = Chen | first2 = YH. | last3 = Man | first3 = KM. | last4 = Shen | first4 = JL. | last5 = Chen | first5 = WC. | title = Papillary adenocarcinoma of rete testis mimics inflammatory lump: a case report. | journal = Case Rep Urol | volume = 2011 | issue = | pages = 857812 | month = | year = 2011 | doi = 10.1155/2011/857812 | PMID = 22606627 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350189/figure/fig3/ ART (nih.gov)].<ref>{{Cite journal | last1 = Wu | first1 = CA. | last2 = Chen | first2 = YH. | last3 = Man | first3 = KM. | last4 = Shen | first4 = JL. | last5 = Chen | first5 = WC. | title = Papillary adenocarcinoma of rete testis mimics inflammatory lump: a case report. | journal = Case Rep Urol | volume = 2011 | issue = | pages = 857812 | month = | year = 2011 | doi = 10.1155/2011/857812 | PMID = 22606627 }}</ref> | ||
==IHC== | |||
Features:<ref name=pmid23800084/> | |||
*[[CK7]] +ve. | |||
*[[EMA]] +ve. | |||
Others:<ref name=pmid23800084/> | |||
*[[AFP]] -ve. | |||
*CD30 -ve. | |||
*PLAP -ve. | |||
*CK5/6 -ve. | |||
*Calretinin -ve. | |||
*[[PSA]] -ve. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Testis]] | [[Category:Testis]] | ||