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# | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Adamantinoma_-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Adamantinoma. [[H&E stain]]. | |||
| Micro = biphasic tumour - epithelial component & fibro-osseous component | |||
| Subtypes = classic, differentiated | |||
| LMDDx = [[vascular tumours]] ([[epithelioid hemangioendothelioma]]), [[metastatic carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]] - classically tibia, other sites | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign +/-locally aggressive | |||
| Other = | |||
| ClinDDx = [[osteosarcoma]] | |||
}} | |||
'''Adamantinoma''' is an uncommon benign [[bone tumour]]. | |||
It should '''not''' be confused with ''[[adenomatoid tumour]]''. | |||
==General== | |||
Features:<ref name=Ref_WMSP650>{{Ref WMSP|650}}</ref> | |||
*Rare: < 1% of bone tumours. | |||
*Typically 25-35 years old. | |||
*Benign, may be locally aggressive. | |||
==Gross== | |||
*Classically mid portion of tibia.<ref name=pmid18279517/> | |||
**Fibula common. | |||
**Reported in many other sites. | |||
===Radiology=== | |||
*Intracortical, radiolucent. | |||
==Microscopic== | |||
Features: | |||
*Biphasic tumour:<ref name=pmid18279517/> | |||
*#Fibro-osseous component. | |||
*#*Spindle cells. | |||
*#Epithelial component. | |||
*#*Classically nests of basaloid cells. | |||
Note: | |||
*It is described as resembling [[ameloblastoma]],<ref name=pmid18279517/> but the resemblance isn't striking. | |||
DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref> | |||
*Vascular tumours ([[epithelioid hemangioendothelioma]]). | |||
*[[Metastatic carcinoma]]. | |||
===Subtypes=== | |||
Subdivided into:<ref name=pmid18279517/> | |||
*Classic. | |||
*Differentiated - less than 20 years old only. | |||
===Images=== | |||
<gallery> | |||
Image:Adamantinoma_-_intermed_mag.jpg | Adamantinoma - intermed. mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue = | pages = 8 | month = | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)]. | |||
*[http://www.tumorlibrary.com/case/images/1878.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1890.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1891.jpg Adamantinoma (tumorlibrary.com)]. | |||
*Epithelium can be focal - Diagnostico Med Br [http://www.diagnostico.med.br/osteopat/54d.JPG] | |||
==IHC== | |||
Features:<ref name=pathcon_adam/> | |||
*CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref> | |||
*[[CK19]] +ve (LMWK). | |||
*CK8/18 -ve (LMWK). | |||
==See also== | |||
*[[Chondro-osseous tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
==External links== | |||
*[http://www.tumorlibrary.com/case/list.jsp?category=Bone+Tumors&category_type=Adamantinoma&order=diagnosis+ASC Adamantinoma case (tumorlibrary.com)]. | |||
[[Category:Diagnosis]] | |||
[[Category:Chondro-osseous tumours]] | |||