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Difference between revisions of "Adamantinoma"
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| Micro = biphasic tumour - epithelial component & fibro-osseous component | | Micro = biphasic tumour - epithelial component & fibro-osseous component | ||
| Subtypes = classic, differentiated | | Subtypes = classic, differentiated | ||
| LMDDx = | | LMDDx = [[vascular tumours]] ([[epithelioid hemangioendothelioma]]), [[metastatic carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 14: | Line 14: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[bone]] - | | Site = [[bone]] - classically tibia, other sites | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Line 28: | Line 28: | ||
| ClinDDx = [[osteosarcoma]] | | ClinDDx = [[osteosarcoma]] | ||
}} | }} | ||
'''Adamantinoma''' is an uncommon benign [[bone tumour]]. It should '''not''' be confused with ''[[adenomatoid tumour]]''. | '''Adamantinoma''' is an uncommon benign [[bone tumour]]. | ||
It should '''not''' be confused with ''[[adenomatoid tumour]]''. | |||
==General== | ==General== | ||
Features:<ref name=Ref_WMSP650>{{Ref WMSP|650}}</ref> | Features:<ref name=Ref_WMSP650>{{Ref WMSP|650}}</ref> | ||
*Rare: < 1% of bone tumours. | *Rare: < 1% of bone tumours. | ||
*25-35 years old. | *Typically 25-35 years old. | ||
*Benign, may be locally aggressive. | *Benign, may be locally aggressive. | ||
==Gross== | ==Gross== | ||
*Classically mid portion of tibia.<ref name=pmid18279517/> | *Classically mid portion of tibia.<ref name=pmid18279517/> | ||
** | **Fibula common. | ||
**Reported in many other sites. | |||
===Radiology=== | ===Radiology=== | ||
| Line 52: | Line 55: | ||
Note: | Note: | ||
* | *It is described as resembling [[ameloblastoma]],<ref name=pmid18279517/> but the resemblance isn't striking. | ||
DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref> | DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref> | ||
*Vascular tumours ([[ | *Vascular tumours ([[epithelioid hemangioendothelioma]]). | ||
*[[Metastatic carcinoma]]. | *[[Metastatic carcinoma]]. | ||
| Line 71: | Line 74: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue = | pages = 8 | month = | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue = | pages = 8 | month = | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)]. | ||
*[http://www.tumorlibrary.com/case/images/1878.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1890.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1891.jpg Adamantinoma (tumorlibrary.com)]. | |||
*Epithelium can be focal - Diagnostico Med Br [http://www.diagnostico.med.br/osteopat/54d.JPG] | |||
==IHC== | ==IHC== | ||
Features:<ref name=pathcon_adam/> | Features:<ref name=pathcon_adam/> | ||
*CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref> | *CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref> | ||
*CK19 +ve (LMWK). | *[[CK19]] +ve (LMWK). | ||
*CK8/18 -ve (LMWK). | *CK8/18 -ve (LMWK). | ||
| Line 83: | Line 90: | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
==External links== | |||
*[http://www.tumorlibrary.com/case/list.jsp?category=Bone+Tumors&category_type=Adamantinoma&order=diagnosis+ASC Adamantinoma case (tumorlibrary.com)]. | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Chondro-osseous tumours]] | [[Category:Chondro-osseous tumours]] | ||