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'''Adamantinoma''' is an uncommon benign [[bone tumour]]. It should '''not''' be confused with ''[[adenomatoid tumour]]''. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Adamantinoma_-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Adamantinoma. [[H&E stain]]. | |||
| Micro = biphasic tumour - epithelial component & fibro-osseous component | |||
| Subtypes = classic, differentiated | |||
| LMDDx = [[vascular tumours]] ([[epithelioid hemangioendothelioma]]), [[metastatic carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]] - classically tibia, other sites | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign +/-locally aggressive | |||
| Other = | |||
| ClinDDx = [[osteosarcoma]] | |||
}} | |||
'''Adamantinoma''' is an uncommon benign [[bone tumour]]. | |||
It should '''not''' be confused with ''[[adenomatoid tumour]]''. | |||
==General== | ==General== | ||
Features:<ref name=Ref_WMSP650>{{Ref WMSP|650}}</ref> | Features:<ref name=Ref_WMSP650>{{Ref WMSP|650}}</ref> | ||
*Rare: < 1% of bone tumours. | *Rare: < 1% of bone tumours. | ||
*25-35 years old. | *Typically 25-35 years old. | ||
*Benign, may be locally aggressive. | *Benign, may be locally aggressive. | ||
==Gross== | ==Gross== | ||
* | *Classically mid portion of tibia.<ref name=pmid18279517/> | ||
**Fibula common. | |||
**Reported in many other sites. | |||
===Radiology=== | ===Radiology=== | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Biphasic tumour: | *Biphasic tumour:<ref name=pmid18279517/> | ||
*# | *#Fibro-osseous component. | ||
*#*Spindle cells. | |||
*#Epithelial component. | *#Epithelial component. | ||
*#*Classically nests of basaloid cells. | |||
Note: | |||
*It is described as resembling [[ameloblastoma]],<ref name=pmid18279517/> but the resemblance isn't striking. | |||
DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref> | DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref> | ||
*Vascular tumours ([[ | *Vascular tumours ([[epithelioid hemangioendothelioma]]). | ||
*[[Metastatic carcinoma]]. | *[[Metastatic carcinoma]]. | ||
===Subtypes=== | |||
Subdivided into:<ref name=pmid18279517/> | |||
*Classic. | |||
*Differentiated - less than 20 years old only. | |||
===Images=== | ===Images=== | ||
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www: | www: | ||
*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref> | *[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue = | pages = 8 | month = | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)]. | |||
*[http://www.tumorlibrary.com/case/images/1878.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1890.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1891.jpg Adamantinoma (tumorlibrary.com)]. | |||
*Epithelium can be focal - Diagnostico Med Br [http://www.diagnostico.med.br/osteopat/54d.JPG] | |||
==IHC== | ==IHC== | ||
Features:<ref name=pathcon_adam/> | Features:<ref name=pathcon_adam/> | ||
*CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref> | *CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref> | ||
*CK19 +ve (LMWK). | *[[CK19]] +ve (LMWK). | ||
*CK8/18 -ve (LMWK). | *CK8/18 -ve (LMWK). | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
==External links== | |||
*[http://www.tumorlibrary.com/case/list.jsp?category=Bone+Tumors&category_type=Adamantinoma&order=diagnosis+ASC Adamantinoma case (tumorlibrary.com)]. | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Chondro-osseous tumours]] | [[Category:Chondro-osseous tumours]] |
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