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Difference between revisions of "Acute myeloid leukemia"
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[[Image:Auer_rods.PNG|thumb|right|Auer rods characterize ''acute myeloid leukemia''.]] | |||
'''Acute myeloid leukemia''', abbreviated '''AML''', is a group of [[cancer|malignancies]]. | '''Acute myeloid leukemia''', abbreviated '''AML''', is a group of [[cancer|malignancies]]. | ||
=Overview= | |||
*Group of malignancies. | |||
*Defined by the cytogenetic abnormalities. | |||
=No recurrent cytogenetic abnormalities= | =No recurrent cytogenetic abnormalities= | ||
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*Associated with [[DIC]]. | *Associated with [[DIC]]. | ||
*Treatment: all-trans retinoic acid (ATRA). | *Treatment: all-trans retinoic acid (ATRA). | ||
===Microscopic=== | ===Microscopic=== | ||
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*CD34 -ve, HLA-DR -ve. | *CD34 -ve, HLA-DR -ve. | ||
*CD33 +ve, CD13 +ve/-ve, CD117 +ve (weak), CD56 +ve/-ve. | *CD33 +ve, CD13 +ve/-ve, CD117 +ve (weak), CD56 +ve/-ve. | ||
===Molecular=== | |||
Variants: | |||
*t(11;17) -- ATRA doesn't work.<ref>{{Ref APBR|623 Q2}}</ref> | |||
*t(17;17) -- ATRA doesn't work. | |||
*t(5;17). (???) | |||
==Acute myeloid leukemia with t(9;11)== | ==Acute myeloid leukemia with t(9;11)== | ||