Thrombotic microangiopathy

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Thrombotic microangiopathy is a group of disorders affecting small blood vessels. Microangiopathic is a disease affecting small blood vessels.[1]

The grouping includes:[2][3]

Others:

Microscopic

Features:[4]

  1. Microvascular occlusion.[5]
  2. "Loose" intimal thickening; fluffy appearing intima.
  3. Fibrin entrapped RBCs.

Notes:

  • Microvascular occlusion is non-specific -- also seen in DIC.
  • The last two (#2 and #3) are useful for discrimination from endarteritis.[4]

See also

References

  1. URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
  2. URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 November 2010.
  3. Mayer SA, Aledort LM (May 2005). "Thrombotic microangiopathy: differential diagnosis, pathophysiology and therapeutic strategies". Mt. Sinai J. Med. 72 (3): 166–75. PMID 15915311.
  4. 4.0 4.1 Fogo, Agnes; Bruijn, Jan A.; Cohen, Arthur H.; Colvin, Robert B.;Jennette, J. Charles (2006). Fundamentals of Renal Pathology (1st ed.). Springer. pp. 204. ISBN 978-0387311265.
  5. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 670. ISBN 978-1416031215.