Lymphoepithelioma-like carcinoma
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Lymphoepithelioma-like carcinoma, abbreviated LELC, is a very rare, poorly differentiated, malignant epithelial tumour.
General
It is thought to be related to nasopharyngeal carcinoma (AKA lymphoepithelioma).[1][2]
Epidemiology:
- Common in Inuit and some Asians.[3]
Etiology:
Microscopic
Features:
- Clusters of cohesive squamoid cells with:
- Aundant dense eosinophilic cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
- Surrounded by a prominent lymphoid component - key feature.
DDx:
Images:
See also
References
- ↑ 1.0 1.1 Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications.". Nat Clin Pract Urol 4 (3): 167-71. doi:10.1038/ncpuro0725. PMID 17347662.
- ↑ 2.0 2.1 URL: http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html. Accessed on: 11 May 2011.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7. Accessed on: 11 May 2011.