Talk:Prostate cancer grading

Separate nodule upgrading

Comment: The World Health Organization (WHO) grade (group) is: 4 out of 5.

Gleason pattern 3 represents 15% of the cancer, and Gleason pattern 4 represents 85% of the cancer. The Gleason pattern 4 is concentrated in a nodule at the apex; the overall grade is based on this (separate) nodule.

Is grading of the index (dominant) nodule in prostate cancer of greater prognostic significance than global grading? https://doi.org/10.1016/j.pathol.2023.08.005

Index grade group is superior to composite grade group for prediction of biochemical recurrence following radical prostatectomy https://doi.org/10.1016/j.pathol.2022.10.012

Poorly formed glands - Gleason 4

https://www.ncbi.nlm.nih.gov/pubmed/26099009

Update

• ISUP https://pubmed.ncbi.nlm.nih.gov/31279442/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382533/
• GUPS https://pubmed.ncbi.nlm.nih.gov/32589068/