Mesonephric adenocarcinoma
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Mesonephric adenocarcinoma is a rare malignant tumour of the uterine cervix.
General
- Arises from the mesonephric duct remnants.
Microscopic
Features:[1]
- Nuclear atypia - key feature.
- Nuclear crowding.
- Variable architecture:
- Tubular, papillary, solid, retiform (net-like[2]).
DDx:
- Mesonephric duct remnants.
- Cervical adenocarcinoma.
- Colorectal adenocarcinoma.
- Endometrioid adenocarcinoma.
- Clear cell adenocarcinoma of the uterus.
IHC
Features:[1]
- CK7 +ve.
- CD10 +ve.
- AMACR +ve.
- Napsin A +ve.[3]
- HNF-1beta +ve/-ve.
- Not useful for differentiation from clear cell carcinoma of the gynecologic tract.[3]
Others:[1]
- CK20 -ve.
- ER -ve.
- PR -ve.
- CEA -ve.
See also
References
- ↑ 1.0 1.1 1.2 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 442. ISBN 978-0781765275.
- ↑ URL: http://www.thefreedictionary.com/retiform. Accessed on: 25 August 2012.
- ↑ 3.0 3.1 Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L (September 2020). "Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract". Appl Immunohistochem Mol Morphol 28 (8): 593–601. doi:10.1097/PAI.0000000000000801. PMC 6987010. PMID 31361605. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987010/.