Low-grade oncocytic renal tumour
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Renal oncocytic tumour that is CD117 negative and CK7 positive, also known as low grade oncocytic renal tumour, is an unusual renal tumour that does not neatly fit into any WHO renal neoplasia category.
Whether it is a distinct entity is not clear as of 2019.[1]
General
- Very rare.
- Benign behaviour based on a small series.[1]
Microscopic
Features:[2]
- Oncocytic cytoplasm.
- Round nuclei.
- Tubular or solid architecture.
- Edematous areas with loosly arranged cells.
- Low ISUP nucleolar grade - grade 1 or 2.
DDx:
- Renal oncocytoma.
- Chromophobe renal cell carcinoma.
- Renal hybrid oncocytic/chromophobe tumour.
- Renal cell carcinoma, unclassified.
- Renal tumours with eosinophilic cytoplasm.
Images
LGORT - low mag. (WC)
LGORT - intermed. mag. (WC)
LGORT - intermed. mag. (WC)
LGORT - high mag. (WC)
LGORT - high mag. (WC)
LGORT - high mag. (WC)
IHC
Features:
- CK7 +ve.
- CD117 -ve.
Others:
- CD10 -ve/+ve.
- AMACR -ve/+ve.
- CA9 -ve.
- CK20 -ve.
- CD10 -ve.
See also
References
- ↑ 1.0 1.1 Trpkov K, Williamson SR, Gao Y, Martinek P, Cheng L, Sangoi AR, Yilmaz A, Wang C, San Miguel Fraile P, Perez Montiel DM, Bulimbasić S, Rogala J, Hes O (August 2019). "Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive): a distinct entity?". Histopathology 75 (2): 174–184. doi:10.1111/his.13865. PMID 30895640.
- ↑ Trpkov K, Williamson S, Martinek P, Cheng L, San Miguel Fraile P, Yilmaz A, Hes O, Oncocytic Renal Tumors with CD117 Negative, Cytokeratin 7 Positive Immunoprofile are Different from Eosinophilic Chromophobe Renal Cell Carcinoma (ChrRCC) and Oncocytoma. United States and Canadian Academy of Pathology Annual Meeting 2018.