Lipofuscin

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Lipofuscin is benign pigment that can be confused for melanin. It is also known as age pigment, as it as associated strongly with aging.[1]

Micrograph showing lipofuscin in the colon; this is known as pseudomelanosis coli. H&E stain.
Micrograph showing stromal lipofuscinosis. H&E stain.

Called "melanosis" when it is really lipofuscin

Microscopic

Features:

  • Brown pigment.

DDx:

  • Melanin.
  • Iron.
  • Bile.
  • Exogenous pigment.

Stains

Features:

See also

References

  1. 1.0 1.1 "Pigments in aging: an overview". Ann. N. Y. Acad. Sci. 959: 57–65. April 2002. doi:10.1111/j.1749-6632.2002.tb02083.x. PMID 11976186.
  2. "Lipofuscin pigmentation (so called "melanosis") of the bladder". Diagn. Cytopathol. 47 (9): 968–971. September 2019. doi:10.1002/dc.24204. PMID 31148387.
  3. Freeman HJ (July 2008). ""Melanosis" in the small and large intestine". World J. Gastroenterol. 14 (27): 4296-9. PMID 18666316. http://www.wjgnet.com/1007-9327/14/4296.asp.